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Alexandre Boyer, PhD

Invited Professor
Université de Montréal
Département de Biomédecine vétérinaire
3200, rue Sicotte, St-Hyacinthe, Qc, J2S 2M2
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Telephone: 450 773-8521 ext. 8345                                  
Fax: 450 778-8103

 Formation

  • B. Sc. Biology, biotechnology concentration (Université de Sherbrooke, 2000)
  • Ph.D. Molecular biology (Université de Montréal, 2006)
  • Postdoctoral fellow: Molecular and cellular biology (Baylor College of Medicine/Université de Montréal, 2006-2009)
  • Postodctoral fellow: Molecular endocrinology  (McGill University, 2010-2011)

Research Interest

  • Hippo pathway
  • Leydig and Sertoli cells functions
  • Infertility
  • Molecular endocrinology
  • Steroidogenesis

The Hippo signaling pathway is involved in many biological processes including embryonic development, adult tissue homeostasis, maintenance of progenitor cell types and cell fate determination and differentiation. Using cell culture and transgenic mouse models, my laboratory is interested in studying the functions of this pathway in the hypothalamic-pituitary-gonadal axis.

Lab members

 Name

Position

Adresse courriel

Adrien Levasseur

Étudiant au PhD

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Publications

Boyer A, Girard M, Thimmanahalli D, Levasseur A, Céleste C, Paquet M, Duggavathi R, Boerboom D. mTOR regulates gap junction alpha-1 protein trafficking in Sertoli cells and is required for the maintenance of spermatogenesis in mice. Biology of reproduction, 2016, 95(1) : 13.

Savard C, Nogues P, Boyer A, Chorfi Y. Prevention of deoxynivalenol- and zearalenone-associated oxidative stress does not restore MA-10 Leydig cell functions. Toxicology. 2016, 341-343:17-27.

Abedini A, Zamberlam G, Lapointe E, Tourigny C,Boyer A, Paquet M, Hayashi K, Honda H, Kikuchi A, Price C,BoerboomD. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016, 30(4):1534-47.

BoerboomD, Kumar V,Boyer A, Wang Y, Lambrot R, Zhou X, Rico C, Boehm U, Paquet M, Céleste C, Kimmins S, Bernard DJ. β-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo. Endocrinology. 2015, 156(1):323-33.

Tsoi M, Laguë MN, Boyer A, Paquet M, Nadeau ME, Boerboom D. Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor. Transl Oncol. 2013, 6(3):226-33.

Lapointe E, Boyer A, Rico C, Paquet M, Gossen J, DeMayo FJ, Richards JS, Boerboom D. Fzd1 regulates cumulus expansion genes and is required for normal female fertility. Biol Reprod. 2012, 87(5):104.

Boyer A, Yeh JR, Zhang X, Paquet M, Gaudin A, Nagano MC, Boerboom D. Ctnnb1 signaling in Sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS one. 2012, 7(1):e29764.

Laguë MN, Romieu-Mourez R, Bonneil E, Boyer A, Pouletty P, Mes-Masson AM, Thibault P, Nadeau ME, Boerboom D. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human
cancers. PLoS one. 2012, 7(8):e42470.

Richards JS, Fan HY, Liu Z, Tsoi M, Boyer A, Boerboom D. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis. Oncogene. 2012, 31(12):1504-20.

Boerboom D, Lafond JF, Zheng X, Lapointe E, Mittaz L, Boyer A, Pritchard M, DeMayo F, Mort J, Drolet R, Richards JS. Partially redundant function of Adamts1 and Adamts4 in the perinatal development of the renal medulla. Dev Dyn. 2011, 240(7):1806-14.

Boyer A, Lapointe E, Zheng X, Cowan RG, Li H, Quirk SM, DeMayo FJ, Richards JS, Boerboom D. WNT4 is required for normal ovarian follicle development and female fertility. FASEB, 2010, 24(8):3010-25.

Boyer A, Goff AK, Boerboom D. WNT signaling in ovarian follicle biology and tumorigenesis. Trends Endocrinol Metab. 2010, 21(1):25-32.

Laguë MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson L, Boerboom D. Decidual PTEN expression is required for trophoblast invasion in the mouse. Am J Physiol Endocrinol Metab, 2010. 299(6):E936-46.

Boyer A, Hermo L, Paquet M, Laguë MN, Boerboom D. Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis, 2009, 30(5): 869-78.

Boyer A, Hermo L, Paquet M, Robaire B, Boerboom D. Sustained activation of Wnt/β-catenin signaling in Sertoli cells causes seminiferous tubule degeneration and germ cell loss. Biology of Reproduction, 2008, 79(3):475-85.

Joubert P, Cordeau ME, Boyer A, Silversides DW, Lavoie JP. Cytokine expression by peripheral blood neutrophils from heaves-affected horses before and after allergen challenge. Vet J. 2008. 178(2):227-32.

Cory AT, Boyer A, Pilon N, Lussier J, Silversides DW. Presumptive pre-Sertoli cells express genes involved in cell proliferation and cell signalling during a critical window in early testis differentiation. Mol Reprod Dev. 2007, 74(12):1491-504.

Boyer A, Pilon N, Raiwet D, Lussier JG, Silversides DW. Human and pig SRY 5’ flanking sequences can direct reporter transgene expression to the genital ridge and to the neural crest cells. Dev Dynamics, 2006, 235(3):623-32.

Boyer A, Lussier JG, Sinclair AH, McClive PJ, Silversides DW. Pre-Sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination. Biology of reproduction. 2004, 71(3): 820-7.

Boyer A, Paquet M, Raiwet D, Daneau I, Harrison W, Silversides DW. Rapididentification of transgenic integration sites for mouse insertional mutants. Biotechniques. 2003, 34(1):32-4, 36.

Boyer A, Dornan S, Daneau I, Lussier JG, Silversides DW. Conservation of the function of DMRT1 regulatory sequences in mammalian sex differentiation. Genesis. 2002, 34(4):236-43.

Daneau I, Pilon N, Boyer A, Behdjani R, Overbeek PA, Viger R, Lussier JG, Silversides DW. The porcine SRY promoter is transactivated within a male genital ridge environment. Genesis. 2002, 33(4):170-80.

Silversides DW, Pilon N, Bedhjani R, Boyer A, Daneau I, Lussier JG. Genetic manipulation of sex differentiation and phenotype in domestic animals. Theriogenology. 2001, 55:51-63.


Awards

2014-2019: Subvention à la Découverte, Conseil de recherches en sciences naturelles et en génie du Canada (CRSNG)
Elucidation of the regulatory mechanisms of spermatogonial stem cell fate

2015: Subvention Mitacs accélération
Identification des mécanismes moléculaires et prévention de la toxicité reproductive mâle causée par des combinaisons des fusarotoxines
En collaboration avec le Dr Younès Chorfi et MédiVet

2014: Subvention nouvelles collaborations, Réseau québécois en reproduction (RQR)
The role of WNT signaling in modulating steroidogenesis in Leydig cells
En collaboration avec Jacques J. Tremblay (Université Laval)