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   André Tremblay   

André Tremblay, PhD

Professor

Université de Montréal

Department Obstetrics, Gynecology 

and Biochemistry

CHU Ste-Justine

3175, Côte Ste-Catherine

Montréal, Qc

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Telephone : 514-345-4931 x2830

Fax: 514-345-4988

Field of research:

  • Molecular and cellular biology of nuclear hormone receptors in reproduction and physiology
  • Role of Estrogen Receptors ERa et ERb
  • Regulation of the estrogenic response by groth factor receptors of the EGFR/ErbB family
  • Chemokine-estrogen axis in cell differentiation and growth
  • Role of the PPARg-LXRa-FXR metabolic pathway on lipid metabolism and energy balance
  • Transcriptional regulation, chromatin remodeling, receptor modifications by phosphorylation, ubiquitination and sumoylation

 

Research summary:

Members of the nuclear receptor family function as transcription factors that control the expression of target genes in response to hormonal stimuli and cell signaling pathways. Two classes of receptors are studied in the lab:

  • The estrogen receptors ERα and ERβ are involved in various aspects related to reproduction, sexual differentiation and pregnancy. Besides hormone, the ERs are regulated by other cellular pathways, such as those mediated by growth factor receptors of the EGFR/ErbB family and by chemokine receptors of the GPCR family. Our interest is to understand how these relationships are taking place in order to regulate transcriptional events and gene expression programs.
  • The PPARs (α, β and g) are essential metabolic regulators of glucose, lipid and energy homeostasis, and emerging evidence also include nuclear receptors LXR and FXR in these processes. Our aim is to characterize the molecular and cellular mechanisms involving these receptors, on gene transcription and expression, mitochondrial activity and biogenesis, chromatin remodeling, and regulation by cofactors.

 

Laboratory members:

Name

Position

Email Address

Karine Sauvé

PhD Student

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Meryl Hassan

PDF Student

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Stéphanie Bilodeau

PhD Student

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Samira Benhadjeba

MSc Student

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Sarah Keil

MSc Student

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Lydia Edjekouane

PhD Student

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Véronique Caron

Research Assistant

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Jonathan Gagnon

MSc Student

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List of publications:

  • Rodrigue-Way, A., Bilodeau, S., Hassan, M., Caron, V., Lévy, E., Mitchell, G., Tremblay, A. (2014) Scavenger Receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig-1/2 expression in hepatocytes. FASEB J 28:1910-1923
  • Srour, M., Chitayat, D., Caron, V., Chassaing, N., Bitoun, P., Patry, L., Cordier, M., Capo-Chichi1,J., Rancannet, C., Calvas, P., Ragge, N., Dobrzeniecka, S., Hamdan, F., Rouleau, G., Tremblay, A., Michaud, J.L. (2013) Recessive and dominant mutations in retinoic acid receptor beta in cases with microphthalmia and diaphragmatic hernia. Am J Hum Genetics 93:765–772.
  • Sanchez, M., Picard, N., Sauvé, K., Tremblay, A. (2013) Coordinate regulation of estrogen receptor b degradation by Mdm2 and CREB-binding protein in response to growth signals. Oncogene 32:117-126.
  • Picard, N., Caron, V., Bilodeau, S., Sanchez, M., Mascle, X., Aubry, M., Tremblay, A. (2012) Identification of estrogen receptor b as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by GSK3b. Mol Cell Biol. 32(14):2709-2721.
  • Yoffou, P.H., Edjekouane, L., Meunier, L., Tremblay, A., Provencher, D., Mes-Masson, A.M., Carmona, E. (2011) Subtype specific elevated expression of hyaluronidase-1 (Hyal-1) in epithelial ovarian cancer. PLoS One 6(6):e20705.
  • Sanchez, M., Sauvé, K., Picard, N., Tremblay, A. (2010) Challenging estrogen receptor b with phosphorylation. Trends Endo Met 21(2): 104-110
  • Sauvé, K., Lepage, J., Sanchez, M., Heveker, N., Tremblay, A. (2009) Positive feedback activation of estrogen receptors by the SDF1-CXCR4 pathway. Cancer Research 69: 5793-5800.
  • Demers, A., Rodrigue-Way, A., Tremblay, A. (2008). Hexarelin signaling to PPARg in metabolic disease. PPAR Research 2008:1-9.
  • Picard, N., Charbonneau, C., Sanchez, M., Licznar, A., Busson, M., Lazennec, G., Tremblay, A. (2008) Phosphorylation of AF-1 regulates proteasome-dependent nuclear mobility and E6 ubiquitin ligase recruitment to the estrogen receptor b. Molecular Endocrinology 22: 317-330.
  • Rodrigue-Way, A., Demers, A., Ong, H., Tremblay, A. (2007) A Growth Hormone-Releasing Peptide Promotes Mitochondrial Biogenesis And A Fat Burning-like Phenotype Through Scavenger Receptor CD36 in White Adipocytes. Endocrinology, 148:1009-1018.
  • Sanchez, M., Sauvé, K., Picard, N., Tremblay, A. (2007) Transcriptional repression of the estrogen receptor b by the PI3K/Akt pathway involves a phosphorylation-dependent release of CBP. J. Biol. Chem, 282:4830-4840.
  • Scott, P.A., Tremblay, A., Brochu, M., St-Louis, J. (2007) Vasorelaxant action of 17b–estradiol in rat uterine arteries: role of nitric oxide synthases and estrogen receptors. Am J Physiol Heart Circ Physiol. 293:H3713-3719.
  • Marcil, V., Delvin, E., Sané, A.T., Tremblay, A., Levy, E. (2006) Oxidative stress influences cholesterol efflux in THP-1 macrophages: Role of ATP-binding cassette A1 and nuclear factors. Cardiovascular Research, 72:473–482
  • Avallone, R., Demers, A., Rodrigue-Way, A., Anghel, S., Wahli, W., Marleau, S., Ong, H., Tremblay, A. (2006) A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor upregulates ABC sterol transporters and cholesterol efflux in macrophages through a PPARg-dependent pathway. Molecular Endocrinology, 20:3165-3178.
  • Yang, C., Gagnon, D., Vachon, P., Tremblay, A., Lévy, E., Massie, B., Michaud, J.L. (2006) Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake. Journal of Neuroscience 26:7116-7120.
  • Sanchez, M., Tremblay, A. (2005) Growth factor signaling to estrogen receptors in hormone dependent cancers. Recent Dev. Cancer, 5:149-186.
  • Marleau, S., Harb, D., Bujold, K., Avallone, R., Iken, K., Wang, Y., Demers, A., Sirois, M.G., Febbraio, M., Silverstein, R.L., Tremblay, A., Ong, H. (2005) EP80317, a ligand of CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions. FASEB J. 19:1869-1886
  • St-Laurent, V., Sanchez, M., Charbonneau, C., Tremblay, A. (2005) Selective Hormone-Dependent Repression of Estrogen Receptor b by a p38-Activated ErbB2/ErbB3 Pathway. J. Ster. Biochem. 94:23-37
  • Yang, C., Boucher, F., Tremblay, A., Michaud, J.L. (2004) Regulatory interaction between arylhydrocarbon receptor and Sim1, two basic helix-loop-helix Pas proteins involved in the control of food intake. J. Biol. Chem. 279:9306-9312