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CVT

     Céline Van Themsche, Ph.D.

     Directrice, comité de programmes de cycles supérieurs en Biologie cellulaire et moléculaire

     Professor 

     Université du Québec à Trois-Rivières

     Department: Biologie médicale

     3351, boul. Des Forges, C.P.500

     Trois-Rivières (Qc) G9A 5H7

     CANADA

     Email: This email address is being protected from spambots. You need JavaScript enabled to view it.

     Telephone: 819 376-5011 poste 3370

     Fax: 819 376-5084

     Link: https://oraprdnt.uqtr.uquebec.ca/pls/public/gscw030?owa_no_site=178

 

Field of research:

  • Reproductive Biology
  • Uterine physiology
  • In vitro experiments and animal models

 

Resume of recent results:

We are currently examining the regulation of p53 transcription factor expression and activity in human endometrial stromal cells (ESCs) of the uterus, during a process crucial to female fertility called decidualization. Our working hypothesis is that p53 protein must be inactivated at the beginning of decidualization in ESCs, to allow for cell proliferation, survival and differentiation to take place and therefore, to ensure adequate completion of the decidualization process. Specifically, using a a well-established in vitro model of decidualization of immortalized ESCs, we are evaluating gene and protein expression of p53 and its target genes (including MDM2, Bax, cycline B1, CDC2 and p21), subcellular localization of p53 protein, as well as post-translational modifications (phosphorylation, acétylation, ubiquitation) that this protein is susceptible to in ESCs during decidualization.

 

Laboratory members:

 

Name

Position

Email address

David Beauchemin

Étudiant 3e cycle

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Carol-Ann Joly

Étudiante 2e cycle

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Jessica Dion

Étudiante 2e cycle

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Valérie Leblanc

Professionnelle de recherche

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Roch Tremblay

Étudiant 2e cycle

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Publications (last five years):

  1. Beauchemin D, Lacombe C, Van Themsche C. PAX2 is activated by estradiol in breast cancer cells of the luminal subgroup selectively, to confer a low invasive phenotype. Mol Cancer. 2011 Dec;10:148.

  2. Lafontaine L, Chaudhry P, Lafleur M-J, Van Themsche C, Soares MJ, Asselin E. Transforming Growth Factor-beta Regulates Proliferation and Invasion of Rat Placental Cell Lines. Biol Reprod. 2011 Mar;84(3):553-9.

  3. Van Themsche C, Chaudhry P, Leblanc V, Parent S, Asselin E: XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Mol Cancer 2010, 9:216-222.

  4. Fortier, A.M., Van Themsche, C., Asselin, E., and Cadrin, M. (2010). Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells. FEBS Lett. 584, 984-988.