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      Derek Lab2016
       

Derek Boerboom, DMV, Ph.D.

Associate Professor

Université de Montréal

Département de biomédecine vétérinaire

3200 Sicotte

St-Hyacinthe, Qc

J2S 2M2

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Phone:450-773-8521 ext. 0160

Fax: 450-778-8103

 

Post-secondary education :

B.Sc. Honours biochemistry (McGill, 1993)

M.Sc. Biochemistry (McGill, 1995)

Ph.D. Molecular biology (Montréal, 2000)

D.V.M. (Montréal, 2002)

Postdoc : Baylor College of Medicine (2002-2005)

 

Professional activities:

Member of the Réseau Québecois en Reproduction (RQR) and the Centre de Recherche en Reproduction Animale (CRRA)

Canada Research Chair in Ovarian Molecular Biology and Functional Genomics

Editorial Board member, Endocrinology and Biology of Reproduction

 

Research interests: 

Roles of developmental signaling pathways (WNT, Hippo, Slit/Robo) in the mammalian reproductive system.

 

Lab members and contact information

 

Name

Position

Email Address

Charlène Rico

Research agent

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Guillaume St-Jean PhD Student This email address is being protected from spambots. You need JavaScript enabled to view it.
Mayra Tsoi PhD Student This email address is being protected from spambots. You need JavaScript enabled to view it.
Philippe Godin MSc Student This email address is being protected from spambots. You need JavaScript enabled to view it.
Emmanuelle Martinot Postdoc This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Publications (since 2008):

Feng Y., Cui, P., Lu, X., Hsueh, B., Billig, F.M., Yanez, Z.L., Tomer, R., Boerboom, D., Carmeliet, P., Deisseroth, K., and Hsueh, A.J.W. CLARITY reveals dynamics of ovarian follicular architecture and vasculature in three-dimensions. Scientific Reports Mar 23;7:44810 (2017).

Boyer, A., Girard, M., Thimmanahalli, D.S., Levasseur, A., Céleste, C., Paquet, M., Duggavathi, R. and Boerboom, D. mTOR regulates gap junction alpha-1 protein trafficking in Sertoli cells and is required for the maintenance of spermatogenesis. Biology of Reproduction Jul;95(1):13 (2016).

Abedini, A., Zamberlam, G., Lapointe, E., Tourigny, C., Boyer, A., Paquet, M., Hayashi, K., Honda, H., Kikuchi, A., Price, C.A. and Boerboom, D. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. The FASEB Journal Apr;30(4):1534-1547 (2016).

Dong, Y., Wu, H., Rahman, H.N., Liu, Y., Pasula, S., Tessneer, K.L., Cai, X., Liu, X., Chang, B., McManus, J., Hahn, S., Dong, J., Brophy, M.L., Yu, L., Song, K., Silasi-Mansat, R., Saunders, D., Njoku, C., Song, H., Mehta-D'Souza, P., Towner, R., Lupu, F., McEver, R.P., Xia, L., Boerboom, D., Srinivasan, R.S., and Chen, H. Motif mimetic of epsin perturbs tumor growth and metastasis. Journal of Clinical Investigation Dec 1;125(12):4349-4364 (2015).

Nadeau, M.E., Rico, C., Tsoi, M., Vivancos, M., Filimon, S., Paquet, M. and Boerboom, D. Pharmacological targeting of valosin containing protein (VCP) selectively kills canine lymphoma cells by inducing DNA damage. BMC Cancer Jun 24;15:479 (2015).

Abedini, A., Zamberlam G., Boerboom, D. and Price, C.A. Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle. Molecular and Cellular Endocrinology Mar 5;403:39-45 (2015).

Boerboom, D., Kumar, V., Boyer, A., Lambrot, R., Zhou, X., Wang, Y., Rico, C., Boehm, U., Paquet, M., Céleste, C., Kimmins, S., and Bernard, D.J. β-catenin stabilization in gonadotropes impairs follicle-stimulating hormone synthesis in male mice in vivo. Endocrinology Jan;1(1):323-333 (2015).

Rico, C., Dodelet-Devillers, A., Paquet, M., Tsoi, M., Lapointe, E., Carmeliet, P. and Boerboom, D. HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival. Biology of Reproduction Jun;90(6):135 (2014).

Tsoi, M., Laguë, M.N., Boyer, A., Paquet, M., Nadeau, M.E. and Boerboom, D. Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor.Translational OncologyJun 1;6(3):226-233 (2013).

Fortin, J., Kumar, V., Zhou, X., Auwerx, J., Schoonjans, K., Boerboom, D. and Bernard, D.J. NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo. PLoS One 8(3):e59058 (2013).

Tran, S., Zhou, X., Lafleur, C., Kimmins, S., Boehm, U., Treier, M., Boerboom, D. and Bernard, D.J. Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice. Molecular Endocrinology Mar;27(3):407-421 (2013).

Lapointe, E., Boyer, A., Rico, C., Paquet, M., Franco, H., Gossen, J., DeMayo, F.J., Richards, J.S. and Boerboom, D. FZD1 Regulates cumulus expansion genes and is required for normal female fertility. Biology of Reproduction Nov 1;87(5):104 (2012).

Rico, C., Lagüe, M.N., Lefèvre, P., Dodelet-Devillers, A., Kumar, V., Paquet, M., Nadeau. M.E. and Boerboom, D. Pharmacological targeting of mammalian target of rapamycin (mTOR) inhibits ovarian granulosa cell tumor growth. Carcinogenesis Nov;33(11):2283-92 (2012).

Laguë, M.N., Romieu-Mourez, R., Bonneil, E., Boyer, A., Pouletty, N., Mes-Masson, A.M., Thibault, P., Nadeau, M.E. and Boerboom, D. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers. PLoS One 7(8):e42470 (2012).

Richards, J.S., Fan, H.Y., Liu, Z., Tsoi, M., Laguë, M.N., Boyer, A. and Boerboom, D. Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in ovary and testis. Oncogene Mar 22;31(12):1504-20 (2012).

Boyer, A., Yeh, J.R., Zhang, X., Paquet, M., Gaudin, A., Nagano, M.C. and Boerboom, D. Sustained CTNNB1 signaling in Sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS One 7(1):e29764 (2012).

Deschesne, K., Céleste, C., Boerboom, D. and Theoret, C.L. Hypoxia regulates the expression of extracellular matrix associated proteins in equine dermal fibroblasts via HIF1. Journal of Dermatological Science Jan;65(1):12-8 (2012).


Award:

2011: SSR New Investigator Award


Current funding:

04/14-03/19

Canadian Institutes of Health Research
Operating grants
Bernard, Daniel (PI); Boerboom, Derek (Co-applicant)Project Title: Transcriptional regulation of follicle stimulating hormone synthesis

09/13 - 08/15          

Cancer Research Society
Operating Grant
Boerboom, Derek (PI); Mes-Masson, Anne-Marie (Co-Investigator)
Project Title: Assessment of VCP as a potential diagnostic marker for early-stage and recurrent ovarian cancer
120000$

09/13 - 08/15          

Morris Animal Foundation
First Award
Nadeau, Marie-Ève (PI); Boerboom, Derek (Co-Investigator)
Project Title: Valosin containing protein (VCP): a novel therapeutic target for canine lymphoma
64908$ (US)

05/13 - 04/16          

Le Fonds Québecois de la Recherche sur la nature et les technologies
Projet de Recherche en Équipe
Bernard, Daniel (Leader); Boerboom, Derek and Hébert, Terence (Co-applicants);
Project Title: Importance fonctionnelle d'une divergence évolutive de la structure du récepteur de la gonadolibérine chez les mammifères
135000$

05/13 - 04/14          

Faculté de Médecine Vétérinaire, Université de Montréal
Fonds en santé des animaux de compagnie (FSAC)                                
Nadeau, Marie-Ève (PI); Boerboom, Derek (Co-applicant)
Project title: VCP (Valosin containing protein) : une cible thérapeutique d'intérêt pour le traitement de l'ostéosarcome et du lymphome canin
10000$

04/13 - 03/18          

Canadian Institutes of Health Research
Operating grants
Boerboom, Derek (PI); Clarke, Hugh (Co-applicant)
Project Title: Elucidation of the roles of Wnt signaling in the mammalian ovary
660590$

10/12 - 09/15          

Canadian Institutes of Health Research
Operating grants
Bernard, Daniel (PI); Boerboom, Derek (Co-applicant)
Project Title: Mechanisms of GnRH action
445056$

04/12 - 03/17          

National Science and Engineering Research Council
Discovery grants
Boerboom, Derek (PI)
Project title: Role of development signaling pathways in testicular physiology and spermatogenesis
135000$

06/11 - 05/16          

Canada Research Chairs
Canada Research Chair (Tier II)
Boerboom, Derek (PI)
Project Title: Canada Research Chair in ovarian molecular biology and functional genomics (renewal)
500000$

05/11 - 04/14          

Le Fonds Québecois de la Recherche sur la nature et les technologies
Projet de Recherche en Équipe
Price, Christopher (Leader); Boerboom, Derek and Richard, François (Co-applicants);
Project Title: Nouvelles voies vers l'embryon sain chez les animaux de consommation
123750$