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Eric Asselin

Eric Asselin

         eric   

Éric Asselin, Ph.D.

Titulaire de la Chaire de Recherche du Canada en Gynéco-Oncologie Moléculaire

Director, Groupe de recherche en Oncologie et Endocrinologie Moléculaires

Professor, Département de Chimie-Biologie

Université du Québec à Trois-Rivières

3351, boul. des Forges, C.P. 500

Trois-Rivières, Québec CANADA, G9A 5H7 

Office: (819) 376-5011 ext. 3317

Laboratory: (819) 376-5011 ext. 3359

Fax: (819) 376-5084

E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

WEB: http://www.uqtr.ca/groem

 

Research Interest:  

•  Physiology and endocrinology of cancer and reproduction
•  Molecular Gyneco-Oncology
•  Therapeutic targeting, resistance to  chimiotherapeutic agents and metastasis
•  Moceluar biology
•  Cellular biology
•  Animal experimentations in vivo and in vitro

 

Lab members: 

Nom

Position

Adresse courriel

Sophie Parent

Research Assistant

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Valérie Leblanc

Research Assistant

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Parvesh Chaudhry

Postdoc Student

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Mohan Singh

Postdoc Student

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Sébastien Fortin

Postdoc Student

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Marie-Claude Dery

PhD Student

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Anne-Marie Fortier

PhD Student

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Caroline Descôteaux

PhD Student

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Kevin Brasseur

PhD Student

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Sébastien Baribeau

M.Sc Student

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Annabelle Veillette

M.Sc Student

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François Fabi

M.Sc Student

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Marie-Lise Audet

M.Sc Student

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Kathy Grenier

M.Sc Student

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Jérôme Grenier-Nault

M.Sc Student 

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Publications (5 dernières années):

 

 BOOK CHAPTER (last 5 years)

  1. Fortier AM, Asselin E, Cadrin M. Functional specificity of Akt isoforms in cancer progression. BioMolecular Concepts, 2011; Volume 2, Issue 1-2 . Pages 1-11. ISSN: 1868-503
  2. Chaudhry P and Asselin E. Cell Death and Cell Survival in Chemosensitive and Chemoresistant Gynecological Cancers. In: Cell death Signaling and Cancer. S.G. Pandalai, Managing Editor; Alakananda Basu Editor. Transworld Research Network. 2009; pp187.
  3. Singh M, Chaudhry P and Asselin E. Embryo implantation disorders. In: Pregnancy Disorders And Perinatal Outocomes. Bentham Science Publishers, Editors Julie Lafond and Cathy Vaillancourt. 2012; in press.

ARTICLES IN REFERRED PUBLICATIONS (last 5 years)

  1. Fortier AM, Asselin E*, Cadrin M*. Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. Journal of Biological Chemistry, 2013 Apr 19;288(16):11555-71. * Co-PI and corresponding authors.
  2. Veillette A, Grenier K, Brasseur K, Fréchette-Frigon G, Leblanc V, Parent S, Asselin E. Regulation of the PI 3-K/Akt Survival Pathway in the Rat Endometrium. Biology of Reproduction, 2013; Mar 28;88(3):79.
  3. Singh M, Chandhry P, Asselin E Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. 2013; 2013 May 10;13:233. doi: 10.1186/1471-2407-13-233.
  4. Bastien D, Hanna R, Leblanc V, Asselin E, Bérubé G. Synthesis and preliminary in vitro biological evaluation of 7α-testosterone-chlorambucil hybrid designed for the treatment of prostate cancer. Eur J Med Chem. 2013 Apr 19;64C:442-447. doi: 10.1016/j.ejmech. 2013.04.027
  5. Brasseur K, Leblanc V, Fabi F, Parent S, Descoteaux C, Bérubé G, Asselin E. ERa-targeted therapy in ovarian cancer by a novel estradiol-platinum(II) hybrid. Endocrinology, 2013; May 15; In press.
  6. Chitcholtan K, Asselin E, Parent S, Sykes PH, Evans JJ. Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Exp Cell Res. 2012 Sep 25.
  7. Agudelo D, Bourassa P, Bruneau J, Bérubé G, Asselin E, Tajmir-Riahi HAProbing the Binding Sites of Antibiotic Drugs Doxorubicin and N-(trifluoroacetyl) Doxorubicin with Human and Bovine Serum Albumins. PLoS One, 2012;7(8):e43814.
  8. Girouard J, Lafleur MJ, Parent S, Leblanc V, Asselin E. Involvement of Akt isoforms in chemoresistance of endometrial carcinoma cells. Gynecol Oncol. 2013 Feb;128(2):335-43. doi: 10.1016/j.ygyno.2012.11.016. Epub 2012 Nov 19. PubMed PMID: 23174537.
  9. Dumas G, Dufresne M, Asselin E, Girouard J, Carrier C, Reyes-Moreno C. CD40 pathway activation reveals dual function for macrophages in human endometrial cancer cell survival and invasion. Cancer Immunol Immunother. 2012 Feb;62(2):273-83.
  10. Chaudhry P, Singh M, Asselin E. Prostate apoptosis response-4 (Par-4): a novel substrate of caspase-3 during apoptosis activation. Molecular and Cellular Biology, 2012; 32(4):826-39.
  11. Singh M, Chaudhry P, Parents S, Asselin E. Ubiquitin-proteasomal degradation of COX-2 in TGF-b stimulated human endometrial cells is mediated through endoplasmic reticulum mannosidase I. Endocrinology, 2011; 2012 Jan;153(1):426-37.
  12. Saha P, Fortin S, Leblanc V, Parent S, Asselin E, Bérubé G. Design, synthesis, cytocidal activity and estrogen receptor α affinity of doxorubicin conjugates at 16α-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer. Steroids. 2012 Sep;77(11):1113-22.
  13. Rouette A, Parent S, Girouard J, Leblanc V, Asselin E. Cisplatin increases B-cell lymphoma 2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. International Journal of Cancer, 2012 Apr 15;130(8):1755-67.
  14. Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: Network of hormones, cytokines, and growth factors. Journal of Endocrinology, 2011; Jul;210(1):5-14. Epub 2011 Mar 3.
  15. Descôteaux C, Brasseur K, Leblanc V, Parent S, Asselin E, Bérubé G.SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines. Amino Acids. 2011 Nov 20. [Epub ahead of print]
  16. Saha P, Descôteaux C, Brasseur K, Fortin S, Leblanc V, Parent S, Asselin E, Bérubé G. Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues. Eur J Med Chem. 2011 Dec 17. [Epub ahead of print]
  17. Descôteaux C, Brasseur K, Leblanc V, Parent S, Asselin E, Bérubé G. Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. Steroids. 2011 Dec 29. [Epub ahead of print]
  18. Leduc K, Bourassa V, Asselin E, Leclerc P, Lafond J, Reyes-Moreno C. Leukemia inhibitory factor regulates BeWo cells differentiation through activation of Jak/Stat and Erk1/2 pathways. Immunology and Cell Biology, 2011; Jul;48(12-13):1556-67. Epub 2011 May 23.
  19. Déry MC, Chaudhry P, Leblanc V, Parent S, Fortier AM, Asselin E. Oxytocin Increases Invasive Properties of Endometrial Cancer Cells through Phosphatidylinositol 3-Kinase/Akt-dependent Up-regulation of Cyclooxygenase-1, -2 and X-linked Inhibitor of Apoptosis. Biology of Reproduction, 2011; Dec;85(6):1133-42. Epub 2011 Aug 3.
  20. Dufresne M, Dumas G, Asselin E, Carrier C, Pouliot M, Reyes-Moreno C. Pro-inflammatory type-1 and anti-inflammatory type-2 macrophages differentially modulate cell survival and invasion of human bladder carcinoma T24 cells. Mol Immunol. 2011 Jul;48(12-13):1556-67. Epub 2011 May 23.
  21. Singh M, Parent S, Leblanc V, Asselin E. Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT dependent manner. Biology of Reproduction, 2011; May;84(5):1045-52. Epub 2011 Jan 19.
  22. Descoteaux C, Leblanc V, Brasseur K, Gupta A, Asselin E, Bérubé G. Design, Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines. Bioorg Med Chem Lett. 2010; 20:7388-7392.
  23. Fortier AM, Asselin E, Cadrin M. Functional specificity of Akt isoforms in cancer progression. BioMolecular Concepts, 2012; In press.
  24. Provencher-Mandeville J, Debnath C, Mandal SK, Leblanc V, Parent S, Asselin E, Bérubé G. Design, Synthesis and Biological Evaluation of Estradiol-PEG-Linked Platinum(II) Hybrid Molecules. Comparative Molecular Modeling Study of Three Distinct Families of Hybrids. Steroids, 2010; Jan;76(1-2):94-103. Epub 2010 Oct 30.
  25. Lafontaine L, Chaudhry P, Lafleur MJ, Soares MJ, Asselin E. Transforming Growth Factor-beta regulates proliferation and invasion of rat placental cell lines. Biology of Reproduction, 2010; Mar;84(3):553-9. Epub 2010 Oct 6.
  26. St-louis I, Singh M, Brasseur K, Leblanc V, Parent S, Asselin E. Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids. Reprod Biol & Endocrinol, 2010; Aug 24; 8:103.
  27. Van Themsche C, Chaudhry P, Leblanc V, Parent S, Asselin E. XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Molecular Cancer, 2010; Aug 16; 9:216.
  28. St-Louis I, Fréchette-Frigon G, Asselin E. Expression of COX-1 and COX-2 in the endometrium of pregnant rats and their regulation by sex steroids in vitro and in vivo involvement of Akt activity in this process Reprod Biol & Endocrinol (2010); 8:103.
  29. Bastien D, Leblanc V, Asselin E, Bérubé G. First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2078-81. Epub 2010 Feb 23.
  30. Gupta A, Saha P, Descôteaux C, Leblanc V, Asselin E, Bérubé G. Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1614-8. Epub 2010 Jan 20.
  31. Fortier AM, Van Themsche C, Asselin E, Cadrin M. Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells. FEBS Lett. 2010 Mar 5;584(5):984-8. Epub 2010 Jan 28.
  32. Caron PL, Fréchette-Frigon G, Shooner C, Leblanc V, Asselin E.Transforming growth factor beta isoforms regulation of Akt activity and XIAP levels in rat endometrium during estrous cycle, in a model of pseudopregnancy and in cultured decidual cells. Reprod Biol & Endocrinol. 2009 Aug 5;7:80.
  33. Van Themsche C, Parent S, Leblanc V, Asselin E. XIAP promotes Akt activity by regulating PTEN content and compartmentalization. Journal of Biol Chemistry, 2009; 31;284(31):20462-6. (Accelerated publication).
  34. Van Themsche C, Parent S, Leblanc V, Descôteaux C, Bérubé G, Asselin E. VP-128, a novel estradiol-platinum(II) hybrid with specific antitumour activity towards hormone-dependent breast and ovarian cancer cells in vivo. Endocr Relat Cancer, 2009 Dec;16(4):1185-95. Epub 2009 Aug 6.
  35. Chaudhry P and Asselin E. Resistance to chemotherapy and hormone therapy in endometrial cancer. Endocr Relat Cancer. 2009 Jun;16(2):363-80. Epub 2009 Feb 3.
  36. Gupta A, Mandal SK, Leblanc V, Descôteaux C, Asselin E, Bérubé G. Synthesis and cytotoxic activity of benzopyran-based platinum(II) complexes. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3982-7. Epub 2008 Jun 10.
  37. Descôteaux C, Leblanc V, Bélanger G, Parent S, Asselin E, Bérubé G. Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta. Steroids. 2008 Oct;73(11):1077-89. Epub 2008 Apr 25.
  38. Provencher-Mandeville J, Descôteaux C, Mandal SK, Leblanc V, Asselin E, Berube G. Synthesis of 17b-Estradiol-Platinum(II) Hybrid Molecules Showing Cytotoxic Activity on Breast Cancer Cell Lines. Bioorg Med Chem Lett. 2008; Apr 1;18(7):2282-7. Epub 2008 Mar 6.
  39. Van Themsche C and Asselin E. XIAP levels and PKC activity regulate the sensitivity of endometrial carcinoma cells to TNF alpha-induced apoptosis. Endocrinology, 2008 Aug;149(8):3789-98. Epub 2008 May 8.
  40. N'soukpoé-Kossi CN, Descôteaux C, Asselin E, Bariyanga J, Tajmir-Riahi HA, Bérubé G. Transfer RNA bindings to antitumor estradiol-platinum(II) hybrid and cisplatin. DNA and Cell Biology, 2008 Jun;27(6):337-43.
  41. Gagnon V, Van Themsche C, Turner S, Asselin E. Involvement of Akt activity and XIAP in the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis, 2008; 13: 259-271.
  42. N’soukpoé-Kossi CN, Descôteaux C, Asselin E, Heidar-Ali Tajmir-Riahir, Bérubé G. DNA Interaction with Novel Antitumor Estradiol-Platinum(II) Hybrid Molecule: A Comparative Study with Cisplatin Drug. DNA and Cell Biology, 2008; Jun;27(6):337-43.
  43. Froehlich E, Gupta A, Provencher-Mandeville J, Asselin E, Bariyanga J, Bérubé G, Tajmir-Riahi HA. Study of DNA Interactions with Steroidal and Non-Steroidal Estrogen-Platinum(II) Based Anticancer Drugs. DNA & Cell Biology, 2009; 28: 31-39.
  44. Hurette Chansi KJ, St-Louis I, Parent S, Leblanc V, Shooner C, Asselin E. Regulation of prostaglandin D synthase (PGDS) and prostacyclin synthase (PGIS) in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids. Journal of Endocrinology, 2007; 195:301-311.
  45. Dery MC, Provencher D, Mes-Masson AM and Asselin E. Characterization of a poorly differentiated human endometrial carcinoma cell line: EN-1078D. Reproductive Biology & Endocrinology (2007); Sep 25;5(1):38 [Epub ahead of print].
  46. Mandal S, Bérubé G, Asselin E, Mohammad I, Richardson VJ, Gupta A, Pramanik SK, Williams AL, Mandal SK. A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells.
    Bioorg Med Chem Lett. 2007 June 12; [Epub ahead of print].
  47. Van Themsche C, Parent S, Mathieu I, Asselin E. TGF-b3 increases the invasiveness of endometrial carcinoma cells through PI3-K-dependant upregulation of XIAP and PKC-dependent induction of MMP-9. Journal of Biological Chemistry, 2007 Feb 16;282(7):4794-802. Epub 2006 Dec 6.
  48. Mandal S, Berube G, Asselin E, Richardson VJ, Church JG, Bridson J, Pham TN, Pramanik SK, Mandal SK. A new platinum complex of triazine demonstrates G1 arrest with novel biological profile in human breast cancer cell line, MDA-MB-468.
    Bioorg Med Chem Lett. 2007; 17: 2139-2145.

  

ABSTRACTS IN REFERREED MEETINGS (last 5 years)

  1. Singh M, Chaudhry P, Parent S, Asselin E. Regulation of PTGS2 by TGF-beta in Human Uterine Stromal Cells Through Ubiquitination via Upregulation of MAN1B1. 44th annual meeting of the Society for the Study of Reproduction. Portland, USA. August 2011. Biol Reprod.
  2. Veillette A, Brasseur K, Leblanc V, Parent S, Asselin E. Expression of Akt Isoforms in the Rat Endometrium During Pregnancy and Pseudopregnancy. 44th annual meeting of the Society for the Study of Reproduction. Portland, USA. August 2011. Biol Reprod.
  3. Singh M, Chaudhry P, Asselin E. Transforming growth factor-beta (TGF-b) increases Par-4 expression via activation of Smad and NF-kB in endometrial cancer cells. 102th annual meeting of the American Association for Cancer Research. Orlando, Florida, USA. April 2011. Proceedings of the AACR, Vol.53.
  4. Lafleur MJ, Girouard J and Asselin E. Role of Akt isoforms in chemoresistance of endometrial carcinoma cells 102th annual meeting of the American Association for Cancer Research. Orlando, Florida, USA. April 2011. Proceedings of the AACR, Vol.53.
  5. Brasseur K, Leblanc V, Parent S, Descôteaux C, Bérubé G, Asselin E. ERa-targeted therapy in ovarian cancer cells by 17b-estradiol-linked chemotherapeutic hybrid; VP-128 (E2-Pt(II)). 102th annual meeting of the American Association for Cancer Research. Orlando, Florida, USA. April 2011. Proceedings of the AACR, Vol.53.
  6. Fortier AM, Cadrin M, Asselin E. Vimentin downregulation modulates p53 levels and apoptosis in cancer cells. 102th annual meeting of the American Association for Cancer Research. Orlando, Florida, USA. April 2011. Proceedings of the AACR, Vol.53.
  7. Girouard J and Asselin E. Role of Akt isoforms in chemoresistance of human endometrial carcinoma cells. 101th annual meeting of the American Association for Cancer Research. Washington DC, USA. April 2010. Proceedings of the AACR, Vol.52.
  8. Rouette A, Girouard J, Leblanc V, Parent S and Asselin E. Bcl2 is regulated by PKC and Akt and is associated with resistance to cisplatin in endometrial cancer cells. 101th annual meeting of the American Association for Cancer Research. Washington DC, USA. April 2010. Proceedings of the AACR, Vol.52.
  9. Leblanc V, Descoteaux C, Parent S, Bérube G and Asselin E. Assessment of novel tyrosine-chlorambucil hybrid molecules on a panel of breast, ovarian and uterine cancer cell lines. 101th annual meeting of the American Association for Cancer Research. Washington DC, USA. April 2010. Proceedings of the AACR, Vol.52.
  10. Parent S, Van Themsche C, Leblanc V, Descoteaux C, Provencher-Mandeville J, Belanger G, Bérubé G and Asselin E. Differential response of ERa-targeted therapy in breast and ovarian cancer cells by 17b-estradiol-linked platinum(II) hybrid (E2-Pt(II)), VP-128. 101th annual meeting of the American Association for Cancer Research. Washington DC, USA. April 2010. Proceedings of the AACR, Vol.52.
  11. Fortier AM, Cadrin M and Asselin E. Role of Akt isoforms in regulating intermediate filaments expression in cancer progression. 101th annual meeting of the American Association for Cancer Research. Washington DC, USA. April 2010. Proceedings of the AACR, Vol.52.
  12. Caroline Descôteaux, Valérie Leblanc, Eric Asselin and Gervais Bérubé. Design, synthesis and biological evaluation of tyrosine-chlorambucil hybrids showing activity against breast and ovarian cancers, (238th ACS National Meeting, San Francisco, March 22-26, 2010).
  13. Caroline Descôteaux, Céline Van Themsche, Valérie Leblanc, Sophie Parent, Rana Hanna, Eric Asselin and Gervais Bérubé. Synthesis and biological evaluation of novel estradiol-platinum(II) hybrid molecules designed for site-specific treatment of female cancers, (237th ACS National Meeting, Salt Lake City, UT, March 22-26, 2009).
  14. Rana Hanna, Dominic Bastien, Valérie Leblanc, Caroline Descôteaux, Eric Asselin and Gervais Bérubé, Design, synthesis and biological evaluation of C2-symmetric testosterone dimers as potential antiandrogens for the treatment of prostate cancer,  (92nd Canadian Chemistry Conference and Exhibition, Hamilton, May-June 2009).
  15. Parent S, Van Themsche, Leblanc V, Asselin E. In vivo molecular modulation of P-AKT, XIAP and COX-2 pathways, and cellular proliferation by resveratrol in uteri of immature rats. 41th annual meeting of the Society for the Study of Reproduction. Hawaii, USA. May 2008. Biol Reprod.
  16. Asselin E, Lafontaine L, Van Themsche C. Transforming growth factor-beta regulates proliferation and invasion of rat trophoblastic cells. 41th annual meeting of the Society for the Study of Reproduction. Hawaii, USA. May 2008. Biol Reprod.
  17. Van Themsche C, Gagnon V, Turner S, Leblanc V, Asselin E. Akt and xiap regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. 99th annual meeting of the American Association for Cancer Research. San Diego, USA. April 2008. Proceedings of the AACR, Vol.49.
  18. Rouette A, Van Themsche C, Asselin E. Drug-specific pattern of P53 phosphorylation in endometrial cancer cells. 99th annual meeting of the American Association for Cancer Research. San Diego, USA. April 2008. Proceedings of the AACR, Vol.49.
  19. Bastien D, Asselin E, Bérubé G. Design and synthesis of C2-symmetric testosterone dimers as potential antiandrogen for the treatment of prostate cancer. 99th annual meeting of the American Association for Cancer Research. San Diego, USA. April 2008. Proceedings of the AACR, Vol.49.
  20. Descôteaux C, N'soukpoé-Kossi CN, Parent S, Tajmir-Riahi HA, Asselin E, Bérubé G. DNA interaction and gene activation with new estrogen-platinum(II) compounds: A comparative study with cisplatin. 99th annual meeting of the American Association for Cancer Research. San Diego, USA. April 2008. Proceedings of the AACR, Vol.49.
  21. Gupta A, Leblanc V, Mandal SK, Asselin E, Bérubé G. Synthesis of new benzopyran-based platinum(II) complexes and cytocidal activity on breast cancer cell lines. 99th annual meeting of the American Association for Cancer Research. San Diego, USA. April 2008. Proceedings of the AACR, Vol.49.
  22. Van Themsche C and Asselin E. Endometrial cells promote an invasion-permissive microenvironment by releasing TGF-b3 and MMP-9. 40th annual meeting of the Society for the Study of Reproduction. San Antonio, Texas, USA. July 2007. Biol Reprod. Abst.457.
  23. Lafontaine L, St-Louis I, and Asselin E.Transforming growth factor beta and PI3K/Akt pathway activity regulate rat trophoblast cells invasion. 40th annual meeting of the Society for the Study of Reproduction. San Antonio, Texas, USA. July 2007. Biol Reprod. Abst 207.
  24. Dery MC and Asselin E. COX-2 upregulation by oxytocin is mediated by the PI 3-K/Akt signaling pathway in endometrial cancer. 100th annual meeting of the American Association for Cancer Research. Los Angeles, USA. April 2007. Proceedings of the AACR, Vol.48, Abst 285.
  25. Descôteaux C, Provencher-Mandeville J, Van Themsche C, Leblanc V, Bélanger G, Parent S, Gupta A, Asselin E and Bérubé G. Development of unique estrogen-cytotoxic hybrid molecules showing affinity for the estrogen receptor and in vivo anticancer activity. 100th annual meeting of the American Association for Cancer Research. Los Angeles, USA. April 2007. Proceedings of the AACR, Vol.48, Abst 4176.
  26. Turner S, Gagnon V, Parent S and Asselin E. X-linked inhibitor of apoptosis protein and Akt: Two anti-apoptotic proteins involved in chemoresistance of endometrial cancer cells. 100th annual meeting of the American Association for Cancer Research. Los Angeles, USA. April 2007. Proceedings of the AACR, Vol.48, Abst 3589.
  27. Van Themsche C, Parent P, Mathieu I and Asselin E. Transforming growth factor-beta3 increases the invasiveness of endometrial carcinoma cells through phosphatidylinositol 3-kinase-dependent upregulation of X-linked inhibitor of apoptosis and protein kinase C-dependent induction of matrix metalloproteinase-9. 100th annual meeting of the American Association for Cancer Research. Los Angeles, USA. April 2007. Proceedings of the AACR, Vol.48, Abst 3075.
  28. Van Themsche C and Asselin E. Tumor necrosis factor alpha decreases the levels of phosphorylated Akt and induces apoptosis in endometrial carcinoma cells through downregulation of X-linked inhibitor of apoptosis protein. 100th annual meeting of the American Association for Cancer Research. Los Angeles, USA. April 2007. Proceedings of the AACR, Vol.48, Abst 3607.

 

INVITED SPEAKER (last 5 years):

 

Dec 16,

2010

Dept. OB&GYN, McGill University.

XIAP more than just a caspase inhibitor in the reproductive system.

June 16, 2009

INRS, Institut Armand-Frapier

L’inhibiteur d’apoptose XIAP est plus qu'un inhibiteur de caspases

May 27, 2009

Centre hospitalier Universitaire de Montréal, Institut du Cancer de Montréal, Université de Montréal

Le contrôle de la survie cellulaire: XIAP est plus qu'un inhibiteur de caspases

May 11, 2009

Colloque: Les frontières de la signalisation cellulaire des tissus reproductifs. ACFAS, Ottawa.

XIAP est plus qu’un inhibiteur d’apoptose dans l’utérus.

April 29, 2009

Collège Laflèche, Trois-Rivières.

À la recherche de médicaments pour la lutte aux cancers gynécologiques.

April 28, 2007

Université de Sherbrooke.

Survie cellulaire et apoptose dans l’endomètre humain.

March 18, 2009

Centre BioMed, UQAM.

Régulation de la survie cellulaire dans l’endomètre humain.

October 8, 2008

Déjeunés de la recherche, Chambre de commerce de la Mauricie, Trois-Rivières.

Les chercheurs sortent leurs armes pour combattre le cancer.

October 13,

2007

10th International Symposium on Molecular Medicine, Hersonissos, Crete, Greece.

Akt involvement in chemoresistance of endometrial cancers.

March 15, 2006

INRS, Institut Armand-Frapier

La survie et la mort cellulaire dans l'endomètre utérin: une étude physiologique et pathologique.

February 18, 2005

Centre de recherche en cancérologie, Hôtel Dieu de Québec, Université Laval

Le cancer endométrial humain: survie cellulaire, apoptose, chimiothérapie et thérapie génique.

June 2, 2004

Centre hospitalier Universitaire de Montréal, Institut du Cancer de Montréal, Université de Montréal

Le cancer endométrial humain: contrôle du destin cellulaire par la balance entre les facteurs de survie et de mort programmée.