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Eric Asselin

Eric Asselin

         eric   

Éric Asselin, Ph.D.

Titulaire de la Chaire de Recherche du Canada en Gynéco-Oncologie Moléculaire

Director, Groupe de recherche en Oncologie et Endocrinologie Moléculaires

Professor, Département de Chimie-Biologie

Université du Québec à Trois-Rivières

3351, boul. des Forges, C.P. 500

Trois-Rivières, Québec CANADA, G9A 5H7 

Office: (819) 376-5011 ext. 3317

Laboratory: (819) 376-5011 ext. 3359

Fax: (819) 376-5084

E-Mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

WEB: http://www.uqtr.ca/groem

 

Research Interest:  

•  Physiology and endocrinology of gynecological cancer and reproduction
•  Molecular Gynecology Oncology
•  Therapeutic targeting, resistance to chimiotherapeutic agents and metastasis
•  Molecular biology
•  Cell biology
•  Animal experiments in vivo and cell culture in vitro

 

Lab members: 

Name

Position

Email Address

Sophie Parent

Auxiliaire de recherche

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Kevin Brasseur

Étudiant PhD

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François Fabi

Étudiant PhD

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France-Hélène Joncas

Étudiante MSc

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Kathy Grenier

Étudiante MSc

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Stéphanie Lamontagne

Étudiante MSc

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Publications (5 dernières années):

BOOK CHAPTER (last 5 years)

  1. Singh M, Chaudhry P and Asselin E. Embryo implantation disorders. In: Pregnancy Disorders And Perinatal Outocomes. Bentham Science Publishers, Editors Julie Lafond and Cathy Vaillancourt. 2012; Publishers,US, eBooks, pp. 152. eISBN : 978-1-60805-372-8. doi: 10.2174/97816080537281120101.
  2. Chaudhry P and Asselin E. Cell Death and Cell Survival in Chemosensitive and Chemoresistant Gynecological Cancers. In: Cell death Signaling and Cancer. S.G. Pandalai, Managing Editor; Alakananda Basu Editor. Transworld Research Network. 2009; pp187.
  3. Fortier AM, Asselin E, Cadrin M. Functional specificity of Akt isoforms in cancer progression. BioMolecular Concepts, 2011; Volume 2, Issue 1-2. Pages 1-11. ISSN: 1868-503

 

ARTICLES IN REFERRED PUBLICATIONS (last 5 years)

** Graduate students and postdoctoral supervised are underlined.

  1. Fabi F, and Asselin E. Expression, activation and role of AKTs in the uterus. Reproduction, 2014; Aug 12. pii: REP-14-0270.
  2. Chaudhry P, Fabi F, Singh M, Parent S, Leblanc V, Asselin E. Prostate apoptosis response-4 (Par-4) mediates TGF-b induced epithelial-mesenchymal transition. Cell Death Di, 2014; Feb 6;5:e1044. doi: 10.1038/cddis.2014.7.
  3. Baribeau S, Chaudhry P, Asselin E. Resveratrol inhibits Cisplatin-induced epithelial-to-mesenchymal transition in ovarian cancer cell lines. PLoS One, 2014, Jan 22;9(1):e86987. doi: 10.1371/journal.pone.0086987.
  4. Fortin S, Brasseur K, Morin N, Asselin E, Berube G. New platinum(II) complexes conjugate at position 7alpha of 17beta-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure-activity relationships and biological evaluation. European Journal of Medicinal Chemistry, August 7th, 2013; 68:433-43.
  5. Melançon A, Gagnon V, Milot M, Charest E, Foucher D, Péronnet F, Unson O'Brien CG, Asselin E, Lavoie C. Liver Glucagon Receptors (GluR): Effect of Exercise and Fasting on Binding Characteristics, GluR-mRNA, and GluR Protein Content in Rats. Horm Metab Res. 2013 Aug 5. [Epub ahead of print]
  6. Fortier AM, Asselin E*, Cadrin M*. Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. Journal of Biological Chemistry, 2013 Apr 19;288(16):11555-71. * Co-PI and corresponding authors.
  7. Veillette A, Grenier K, Brasseur K, Fréchette-Frigon G, Leblanc V, Parent S, Asselin E. Regulation of the PI 3-K/Akt Survival Pathway in the Rat Endometrium. Biology of Reproduction, 2013; Mar 28;88(3):79.
  8. Singh M, Chandhry P, Asselin E Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. BMC Cancer; 2013 May 10;13:233. doi: 10.1186/1471-2407-13-233. HIGHLY ACCESS PAPER.
  9. Bastien D, Hanna R, Leblanc V, Asselin E, Bérubé G. Synthesis and preliminary in vitro biological evaluation of 7α-testosterone-chlorambucil hybrid designed for the treatment of prostate cancer. Eur J Med Chem. 2013 Apr 19;64C:442-447.
  10. Brasseur K, Leblanc V, Fabi F, Parent S, Descoteaux C, Bérubé G, Asselin E. ERa-targeted therapy in ovarian cancer by a novel estradiol-platinum(II) hybrid. Endocrinology, 2013 Jul;154(7):2281-95.
  11. Girouard J, Lafleur MJ, Parent S, Leblanc V, Asselin E. Involvement of Akt isoforms in chemoresistance of endometrial carcinoma cells. Gynecol Oncol. 2013 Feb;128(2):335-43. doi: 10.1016/j.ygyno.2012.11.016. Epub 2012 Nov 19. PubMed PMID: 23174537.
  12. Chitcholtan K, Asselin E, Parent S, Sykes PH, Evans JJ. Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer. Exp Cell Res. 2013 Jan 1;319(1):75-87. doi: 10.1016/j.yexcr.2012.09.012. Epub 2012 Sep 25. PubMed PMID: 23022396.
  13. Agudelo D, Bourassa P, Bruneau J, Bérubé G, Asselin E, Tajmir-Riahi HA. Probing the binding sites of antibiotic drugs doxorubicin and N-(trifluoroacetyl) doxorubicin with human and bovine serum albumins. PLoS One. 2012;7(8):e43814. doi: 10.1371/journal.pone.0043814. Epub 2012 Aug 24. PubMed PMID: 22937101; PubMed Central PMCID: PMC3427208.
  14. Dumas G, Dufresne M, Asselin E, Girouard J, Carrier C, Reyes-Moreno C. CD40 pathway activation reveals dual function for macrophages in human endometrial cancer cell survival and invasion. Cancer Immunol Immunother. 2012 Aug 18. [Epub ahead of print] PubMed PMID: 2903346.
  15. Saha P, Fortin S, Leblanc V, Parent S, Asselin É, Bérubé G. Design, synthesis, cytocidal activity and estrogen receptor α affinity of doxorubicin conjugates at 16α-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer. Steroids. 2012 Sep;77(11):1113-22. doi: 10.1016/j.steroids.2012.06.004. Epub 2012 Jul 16. PubMed PMID: 22801351.
  16. Descôteaux C, Brasseur K, Leblanc V, Parent S, Asselin E, Bérubé G. Design of novel tyrosine-nitrogen mustard hybrid molecules active against uterine, ovarian and breast cancer cell lines. Steroids. 2012 Apr;77(5):403-12. doi: 10.1016/j.steroids.2011.12.021. Epub 2011 Dec 29. PubMed PMID: 22227028.
  17. Saha P, Descôteaux C, Brasseur K, Fortin S, Leblanc V, Parent S, Asselin E, Bérubé G. Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues. Eur J Med Chem. 2012 Feb;48:385-90. doi: 10.1016/j.ejmech.2011.12.017. Epub 2011 Dec 17. PubMed PMID: 22209414.
  18. Chaudhry P, Singh M, Parent S, Asselin E. Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation. Mol Cell Biol. 2012 Feb;32(4):826-39. doi: 10.1128/MCB.06321-11. Epub 2011 Dec 19. PubMed PMID: 22184067; PubMed Central PMCID: PMC3272980.
  19. Singh M, Chaudhry P, Parent S, Asselin E. Ubiquitin-proteasomal degradation of COX-2 in TGF-β stimulated human endometrial cells is mediated through endoplasmic reticulum mannosidase I. Endocrinology. 2012 Jan;153(1):426-37. doi: 10.1210/en.2011-1438. Epub 2011 Nov 22. PubMed PMID: 22109885.
  20. Descôteaux C, Brasseur K, Leblanc V, Parent S, Asselin E, Bérubé G. SAR study of tyrosine-chlorambucil hybrid regioisomers; synthesis and biological evaluation against breast cancer cell lines. Amino Acids. 2012 Aug;43(2):923-35. doi: 10.1007/s00726-011-1152-3. Epub 2011 Nov 20. PubMed PMID: 22102055.
  21. Leduc K, Bourassa V, Asselin E, Leclerc P, Lafond J, Reyes-Moreno C. Leukemia inhibitory factor regulates differentiation of trophoblastlike BeWo cells through the activation of JAK/STAT and MAPK3/1 MAP kinase-signaling pathways. Biol Reprod. 2012 Feb 29;86(2):54. doi: 10.1095/biolreprod.111.094334. Print 2012 Feb. PubMed PMID: 22053093.
  22. Déry MC, Chaudhry P, Leblanc V, Parent S, Fortier AM, Asselin E. Oxytocin increases invasive properties of endometrial cancer cells through phosphatidylinositol 3-kinase/AKT-dependent up-regulation of cyclooxygenase-1, -2, and X-linked inhibitor of apoptosis protein. Biol Reprod. 2011 Dec;85(6):1133-42. doi: 10.1095/biolreprod.111.093278. Epub 2011 Aug 3. PubMed PMID: 21816851.
  23. Rouette A, Parent S, Girouard J, Leblanc V, Asselin E. Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. Int J Cancer. 2012 Apr 15;130(8):1755-67. doi: 10.1002/ijc.26183. Epub 2011 Aug 5. PubMed PMID: 21618512.
  24. Dufresne M, Dumas G, Asselin E, Carrier C, Pouliot M, Reyes-Moreno C. Pro-inflammatory type-1 and anti-inflammatory type-2 macrophages differentially modulate cell survival and invasion of human bladder carcinoma T24 cells. Mol Immunol. 2011 Jul;48(12-13):1556-67. doi: 0.1016/j.molimm.2011.04.022. Epub 2011 May 23. PubMed PMID: 21601924.
  25. Singh M, Chaudhry P, Asselin E. Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors. J Endocrinol. 2011 Jul;210(1):5-14. doi: 10.1530/JOE-10-0461. Epub 2011 Mar 3. Review. PubMed PMID: 21372150.
  26. Singh M, Parent S, Leblanc V, Asselin E. Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT-dependent manner. Biol Reprod. 2011 May;84(5):1045-52. doi: 10.1095/biolreprod.110.090076. Epub 2011 Jan 19. PubMed MID: 21248286.
  27. Descôteaux C, Leblanc V, Brasseur K, Gupta A, Asselin E, Bérubé G. Synthesis of D- and L-tyrosine-chlorambucil analogs active against breast cancer cell lines. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7388-92. doi: 10.1016/j.bmcl.2010.10.039. Epub 2010 Oct 21. PubMed PMID: 21051231.
  28. Lafontaine L, Chaudhry P, Lafleur MJ, Van Themsche C, Soares MJ, Asselin E. Transforming growth factor Beta regulates proliferation and invasion of rat placental cell lines. Biol Reprod. 2011 Mar;84(3):553-9. doi: 10.1095/biolreprod.110.086348. Epub 2010 Oct 6. PubMed PMID: 20926802.
  29. Provencher-Mandeville J, Debnath C, Mandal SK, Leblanc V, Parent S, Asselin E, Bérubé G. Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: comparative molecular modeling study of three distinct families of hybrids. Steroids. 2011 Jan;76(1-2):94-103. doi: 10.1016/j.steroids.2010.09.004. Epub 2010 Oct 30. PubMed PMID: 20869376.
  30. St-Louis I, Singh M, Brasseur K, Leblanc V, Parent S, Asselin E. Expression of COX-1 and COX-2 in the endometrium of cyclic, pregnant and in a model of pseudopregnant rats and their regulation by sex steroids. Reprod Biol Endocrinol. 2010 Aug 24;8:103. doi: 10.1186/1477-7827-8-103. PubMed PMID: 20735829; PubMed Central PMCID: PMC2936314.
  31. Van Themsche C, Chaudhry P, Leblanc V, Parent S, Asselin E. XIAP gene expression and function is regulated by autocrine and paracrine TGF-beta signaling. Mol Cancer. 2010 Aug 16;9:216. doi: 10.1186/1476-4598-9-216. PubMed PMID: 20712893; PubMed Central PMCID: PMC2933620.
  32. Bastien D, Leblanc V, Asselin E, Bérubé G. First synthesis of separable isomeric testosterone dimers showing differential activities on prostate cancer cells. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2078-81. doi: 10.1016/j.bmcl.2010.02.077. Epub 2010 Feb 23. PubMed PMID: 20226660.
  33. Gupta A, Saha P, Descôteaux C, Leblanc V, Asselin E, Bérubé G. Design, synthesis and biological evaluation of estradiol-chlorambucil hybrids as anticancer agents. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1614-8. doi: 10.1016/j.bmcl.2010.01.053. Epub 2010 Jan 20. PubMed PMID: 20137939.
  34. Fortier AM, Van Themsche C, Asselin E, Cadrin M. Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells. FEBS Lett. 2010 Mar 5;584(5):984-8. doi: 10.1016/j.febslet.2010.01.045. Epub 2010 Jan 28. PubMed PMID: 20109457.
  35. Van Themsche C, Parent S, Leblanc V, Descôteaux C, Simard AM, Bérubé G, Asselin E. VP-128, a novel oestradiol-platinum(II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo. Endocr Relat Cancer. 2009 Dec;16(4):1185-95. doi: 10.1677/ERC-09-0113. Epub 2009 Aug 6. PubMed PMID: 19661132.
  36. Caron PL, Fréchette-Frigon G, Shooner C, Leblanc V, Asselin E. Transforming growth factor beta isoforms regulation of Akt activity and XIAP levels in rat endometrium during estrous cycle, in a model of pseudopregnancy and in cultured decidual cells. Reprod Biol Endocrinol. 2009 Aug 5;7:80. doi: 10.1186/1477-7827-7-80. PubMed PMID: 19656380; PubMed Central PMCID: PMC2729750.
  37. Van Themsche C, Leblanc V, Parent S, Asselin E. X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. J Biol Chem. 2009 Jul 31;284(31):20462-6. doi: 10.1074/jbc.C109.009522. Epub 2009 May 27. PubMed PMID: 19473982; PubMed Central PMCID: PMC2742810.
  38. Chaudhry P, Asselin E. Resistance to chemotherapy and hormone therapy in endometrial cancer. Endocr Relat Cancer. 2009 Jun;16(2):363-80. doi: 10.1677/ERC-08-0266. Epub 2009 Feb 3. Review. PubMed PMID: 19190080.
  39. Froehlich E, Gupta A, Provencher-Mandeville J, Asselin E, Bariyanga J, Bérubé G, Tajmir-Riahi HA. Study of DNA interactions with steroidal and nonsteroidal estrogen-platinum (II)-based anticancer drugs. DNA Cell Biol. 2009 Jan;28(1):31-9. doi: 10.1089/dna.2008.0804. PubMed PMID: 18928379.

Awards: 

Chaire de Recherche du Canada en Gynéco-Oncologie Moléculaire