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    palin    

Marie-France Palin, Ph.D.

Scientific Researcher, animal genomic

Agriculture et Agroalimentaire Canada

Centre de recherche et de développement sur le bovin laitier et le porc

2000, rue Collège

Sherbrooke, (Québec) J1M 0C8

Téléphone : 819 780-7207

Télécopieur : 819 564-5507

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Research Interests: 

Translation to come

  • Identification de marqueurs moléculaires permettant d'améliorer les caractères de reproduction et de qualité de la viande chez le porc.
  • Effets des acides gras oméga-3 sur la survie embryonnaire et l’implantation chez la vache laitière.
  • Étude de la génomique du tissu adipeux en relation avec les caractères de reproduction chez la truie.
  • Identification de gènes clés impliqués dans le développement de la glande mammaire chez la truie.
  • Rôle des adipokines (facteurs produits par le tissu adipeux) sur la mortalité embryonnaire chez le porc.

 

Summary of Results:

Translation to come

Identification de marqueurs moléculaires permettant d'améliorer les caractères de reproduction chez la truie:

L’adiponectine est l’adipokine la plus abondamment sécrétée par le tissu adipeux et sa sécrétion est négativement corrélée à la masse du tissu adipeux. L’adiponectine exerce plusieurs rôles clés dont les plus connus sont ses effets antidiabétiques et anti-inflammatoires. Il a aussi été démontré que l’adiponectine est impliquée dans la reproduction, plus particulièrement dans les processus de l’ovulation, de l’implantation et de la formation du placenta. L’action de l’adiponectine est modulée par sa liaison aux récepteurs ADIPOR1 et ADIPOR2 que l’on retrouve, en autre, sur différents tissus reproducteurs tels que l’utérus et les ovaires. Récemment, nous avons identifié seize polymorphismes (SNP) dans les gènes de l’adiponectine et de ses récepteurs (ADIPOR1 et ADIPOR2) chez le porc. Parmi ceux-ci, cinq SNP ont été conservés pour effectuer des analyses d’association avec les caractères de reproduction mesurés sur une population de truies Landrace : deux identifiés dans le gène ADIPOQ, un dans celui de l’ADIPOR1 et deux dans ADIPOR2. Certain variants et haplotypes identifiés sont associés à des tailles de portées plus grandes, un plus petit nombre de porcelets morts-nés et momifiés et un intervalle sevrage-oestrus plus court. Ainsi, ces variants et haplotypes pourraient éventuellement servir de marqueurs génétiques de caractères de reproduction et être utilisés dans un programme de sélection génétique dans le but d’améliorer les performances reproductrices des truies. (Pour plus d’information, consulter Houde et al., 2008) 

 

Laboratory members:

Name

Position

Email Address

Danièle Beaudry

Technician

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Catherine Hallé

M.Sc. student

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Awards:

Winner of the award «Pfizer Canada Inc. Young Scientist Award» given by the Canadian society of animal science 2002.

 

List of Publications: 

2011

Lefèvre, P.L.C., Palin, M.F., Chen, G., Turecki, G. and Murphy, B.D. 2011. Polyamines are implicated in the emergence of the embryo from obligate diapause. Endocrinology 152(4):1627-39.

Lefèvre, P.L.C., Palin, M.F., Beaudry, D., Dobias-Goff, M., Desmarais, J.A., Llerena, E.M. and Murphy, B.D. (2011). Uterine Signaling at the Emergence of the Embryo from Obligate Diapause. American Journal of Physiology-Endocrinology and Metabolism. 300(5): E800-808.

Lefèvre, P.L.C., Palin, M.F. and Murphy, B.D. 2011. Polyamines on the reproductive landscape. Submitted to Endocrine Reviews. (In Press)

Farmer, C., Palin, M.F. and Martel-Kennes, Y. (2011) Impact of diet deprivation and subsequent over-allowance during prepuberty on growth performance, metabolite status and mammary gland development in gilts. Journal of Animal Science. (In Press)

 

2010

Brochu-Gaudreau, K., Rehfeldt, C., Blouin, R., Bordignon, V., Murphy, B.D. and Palin, M.F. 2010. Adiponectin action from head to toe. Endocrine 37 (1):11-32. (Invited Review).

Houde, A.A., Méthot, S., Murphy, B.D., Bordignon, V. and Palin, M.F. 2010. Relationships between backfat thickness and reproductive efficiency of sows: a two year trial on two commercial herds fixing their backfat thickness at breeding. Canadian Journal of Animal Science 90 (3):429-436.

Farmer, C., Palin, M.F. and Hovey, R.C. 2010. Greater milk yield is related to increased DNA and RNA content but not to the mRNA abundance of selected genes in sow mammary tissue. Canadian Journal of Animal Science 90 (3):379-388.

Farmer, C., Palin, M.F., Gilani, G.S., Weiler, H., Vignola, M., Choudhary, R.K. and Capuco, A.V. 2010. Dietary genistein stimulates mammary hyperplasia in gilts. Animal 4 (3):454-465.

Preynat, A., Lapierre, H., Thivierge, M.C., Palin, M.F., Cardinault, N., Matte, J.J., Desrochers, A. and Girard, C.L. 2010. Effects of supplementary folic acid and vitamin B12 on hepatic metabolism of dairy cows according to methionine supply. Journal of Dairy Science 93 (5):2130-2142.

Talbot, G., Roy, C.S., Topp, E., Kalmokoff, M.L., Brooks, S.P.J., Beaulieu, C., Palin, M.F. and Massé, D.I. 2010. Spatial distribution of some microbial trophic groups in a plug-flow-type anaerobic bioreactor treating swine manure. Water Science and Technology 61 (5):1147-1155.

 

2009

Labrecque, B., Beaudry, D., Mayhue, M., Hallé, C., Bordignon, V., Murphy, B.D. and Palin, M.F. 2009. Molecular characterization and expression analysis of the porcine paraoxonase 3 (PON3) gene. GENE 443(1-2):110-120.

Labrecque, B., Mathieu, O., Bordignon, V., Murphy, B.D. and Palin, M.F. 2009. Identification of differentially expressed genes in a porcine in vivo model of adipogenesis using suppression subtractive hybridization. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 4 (1):32-44.

Preynat, A., Lapierre, H., Thivierge, C.M., Palin, M.F., Matte, J.J., Desrochers, A. and Girard, C.L. 2009. Effects of supplements of folic acid, vitamin B12 and rumen-protected methionine on whole body metabolism of methionine and glucose in lactating dairy cows. Journal of Dairy Science 92(2):677-689.

Preynat, A., Lapierre, H., Thivierge, C.M., Palin, M.F., Matte, J.J., Desrochers, A. and Girard, C.L. 2009. Influence of methionine supply on the response of lactational performance of dairy cows to supplementary folic acid and vitamin B12. Journal of Dairy Science 92(4):1685-1695.

Roy, C.S., Talbot, G., Topp, E., Beaulieu, C., Palin, M.F. and Massé, D.I. 2009. Bacterial community dynamics in an anaerobic plug-flow type bioreactor treating swine manure. Water Research 43 (1):21-32.

Talbot, G., Roy, C.S., Topp, E., Beaulieu, C., Palin, M.F. and Massé, D.I. 2009. Multivariate statistical analyses of rDNA and rRNA fingerprint data to differentiate microbial communities in swine manure. FEMS Microbiology Ecology 70(3):540-552.

 

2008

Houde, A.A., Murphy, B.D., Mathieu, O., Bordignon, V. and Palin, M.F. 2008. Characterization of swine adiponectin and adiponectin receptor polymorphisms and their association with reproductive traits. Animal Genetics 39(3):249-57.

Palin, M.F., Labrecque, B., Beaudry, D., Mayhue, M., Bordignon, V. and Murphy, B.D. 2008. Visfatin expression is not associated with adipose tissue abundance in the porcine model. Domestic Animal Endocrinology 35 (1):58-73.

Campos, D.B., Palin, M.F., Bordignon, V. and Murphy, B.D. 2008. The “beneficial” adipokines in reproduction and fertility. International Journal of Obesity (London) 32(2):223-231. (Review)

Chappaz, E., Albornoz, M.S., Campos, D., Che, L., Palin, M.F., Murphy, B.D. and Bordignon, V. 2008. Adiponectin enhances in vitro development of swine embryos. Domestic Animal Endocrinology 35 (2):198-207.

Vallée, M., Aiba, K., Piao, Y., Palin, M.F., Ko, M.S. and Sirard, M.A. 2008. Comparative analysis of oocyte transcript profiles reveals a high degree of conservation among species. Reproduction 135(4):439-448.

Farmer, C. and Palin, M.F. 2008. Feeding flaxseed to sows during late-gestation and lactation affects mammary development but not mammary expression of selected genes in their offspring. Canadian Journal of Animal Science 88 (4):585-590.

Talbot, G., Topp, E., Palin, M.F. and Massé, D.I. 2008. Evaluation of molecular methods used for establishing the interactions and functions of microorganisms in anaerobic bioreactors. Water Research 42(3):513-537. (Review)

Petit, H.V. and Palin, M.F. 2008. Letter to the Editor: A Response to the Comments of Rastani and Kertz. Journal of Dairy Science 91:2534.

 

2007

Petit, H.V., Small, J.A., Palin, M.F., Giguère, A. and Santos, G.T.D. 2007. Effects of flaxseed supplementation on endometrial expression of ISG17 and intrauterine prostaglandin concentrations in primiparous dairy cows submitted to GnRH-based synchronized ovulation. Canadian Journal of Animal Science 87 (3):343-352.

Farmer, C., Charagu, P. and Palin, M.F. 2007. Influence of genotype on metabolic variables, colostrum and milk composition of primiparous sows. Canadian Journal of Animal Science 87 (4):511-515.

Graulet, B., Matte, J.J., Desrochers, A., Doepel, L., Palin, M.F. and Girard, C.L. 2007. Effects of dietary supplements of folic acid and vitamin B12 on metabolism of dairy cows in early lactation. Journal of Dairy Science 90 (7):3442-3455.

Petit, H.V., Palin, M.F. and Doepel, L. 2007. Hepatic lipid metabolism in transition dairy cows fed flaxseed. Journal of Dairy Science 90 (10):4780-4792.

 

2006

Lord, E., Murphy, B.D., Desmarais, J.A., Ledoux, S., Beaudry, D. and Palin, M.F. 2006. Modulation of peroxisome proliferator-activated receptor δ and γ transcripts in swine endometrial tissue during early gestation. Reproduction 131 (5):929-942. Corresponding author.

Ledoux, S., Campos, D.B., Lopes, F.L., Dobias-Goff, M., Palin, M.F. and Murphy, B.D. 2006. Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 147 (11):5178-5186.

Boucher, D., Palin, M.F., Castonguay, F., Gariépy, C. and Pothier, F. 2006. Detection of polymorphisms in the ovine leptin (LEP) gene: Association of a single nucleotide polymorphism with muscle growth and meat quality traits. Canadian Journal of Animal Science 86 (1):31-35.

Vallée, M., Robert, C., Méthot, S., Palin, M.F. and Sirard, M.A. 2006. Cross-species hybridizations on a multi-species cDNA microarray to identify evolutionarily conserved genes expressed in oocytes. BMC Genomics 7:113.