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      marilene-paquet1       

Marilène Paquet, DMV, MSc, D'ACVP

Professeur adjoint

Université de Montréal

Département de pathologie et de microbiologie

3200 Sicotte, Pavillon CDEVQ, bureau 1.38

St-Hyacinthe, Qc

J2S 2M2

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Phone: 450 773-8521 ou 514 345-8521, poste 49061

Fax: 450-778-8116

 Titres :

  • Professeur adjoint, Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal
  • Professeur associé, Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal

 

Certificats, licences et affiliations professionnelles :

  • Membre, Centre de Recherche en Reproduction Animale (CRRA), 06/2013-présent
  • Membre, Réseau Québécois en Reproduction (RQR), 07-2013
  • Certificat de Spécialiste en Pathologie Vétérinaire (Ordre des Médecins Vétérinaires du Québec) (obtenu le 05/2007)
  • Certification du Collège Américain des Pathologistes Vétérinaires (diplomate-American College of Veterinary Pathologists) (obtenu le 09/2006)
  • Membre, American College of Veterinary Pathologists (ACVP), 09-2006-présent
  • Permis de pratique de la médecine vétérinaire (Ordre des Médecins Vétérinaires du Québec) obtenu le 07/2000
  • Membre, Ordre des Médecins Vétérinaires du Québec (OMVQ), 05/2000- présent

 

Champs d'intérêts :

  • Oncologie comparée
  • Pathologie comparée et modèles animaux de maladie humaine
  • Physiopathologie du système reproducteur
  • Effets des toxines environnementales sur le système reproducteur

 

Membres du laboratoire :

Nom

Position

Adresse courriel

Guillaume St-Jean

Résident (pathologie) Programme DES-MSc

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Geneviève Langevin- Carpentier

Résidente (pathologie) Programme DES-MSc

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Mayra Tsoi

Étudiante PhD (codirection)

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Liste des publications :

Nadeau, M.E., Rico, C., Tsoi, M., Vivancos, M., Filimon, S., Paquet, M. and Boerboom, D. Pharmacological targeting of valosin containing protein (VCP) selectively kills canine lymphoma cells by inducing DNA damage. BMC Cancer (In Press, 2015)

Boerboom, D., Kumar, V., Boyer, A., Wang, Y., Lambrot, R., Zhou, X., Rico, C., Boehm, U., Paquet, M., Céleste, C., Kimmins, S., Bernard, D.J. β-catenin stabilization in gonadotropes impairs follicle-stimulating hormone synthesis in male mice in vivo. Endocrinology 2014 Oct 24:en20141296.

Stodden, G.R., Lindberg, M.E., King, M.L., Paquet, M., MacLean, J.A., Mann, J.L., DeMayo, F.J., Lydon, J.P., Hayashi, K. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene 2014 Jul 7.

Dauphinee, S.M., Richer, E., Eva, M.M., McIntosh, F., Paquet, M., Dangoor, D., Burkart, C., Zhang, D.E., Gruenheid, S., Gros, P., Behr, M., Malo, D. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. Genes & Immunity 2014 Jul-Aug;15(5):282-92.

Xu, E., Forest, M.P., Schwab, M., Avramoglu, R.K., St-Amand, E., Caron, A.Z., Bellmann, K., Shum, M., Voisin, G., Paquet, M., Montoudis, A., Lévy, E., Siminovitch, K.A., Neel, B.G., Beauchemin, N., Marette, A. Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ. Hepatology 2014 May;59(5):1803-15.

Ramdzan, Z.M., Vadnais, C., Pal, R., Vandal, G., Cadieux, C., Leduy, L., Davoudi, S., Hulea, L., Yao, L., Karnezis, A.N., Paquet, M., Dankort, D., Nepveu, A. RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biology 2014 Mar 11;12(3):e1001807.

Rico, C., Dodelet-Devillers, A., Paquet, M., Tsoi, M., Lapointe, E., Carmeliet, P. and Boerboom, D. HIF1 activity in granulosa cells is required for FSH-regulated Vegfa expression and follicle survival. Biology of Reproduction 2014 Jun;90(6):135

Shio, M.T., Paquet, M., Martel, C., Bosschaerts, T., Stienstra, S., Olivier, M., Fortin, A. Drug delivery by tattooing to treat cutaneous leishmaniasis. Scientific Report 2014 Feb 24;4:4156.

Eva, M.M., Yuki, K.E., Dauphinee, S.M., Schwartzentruber, J.A., Pyzik, M., Paquet, M., Lathrop, M., Majewski, J., Vidal, S.M., Malo, D. Altered IFN-γ-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease. Journal of Immunology 2014 Jan 1;192(1):259-70.

Lambrot, R., Xu, C., Saint-Phar, S., Chountalos, G., Cohen, T., Paquet, M., Suderman, M., Hallett, M., Kimmins, S. Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nature Communications 2013 Dec 10;4:2889.

Malina, A., Mills, J.R., Cencic, R., Yan, Y., Fraser, J., Schippers, L.M., Paquet, M., Dostie, J., Pelletier, J. Repurposing CRISPR/Cas9 for in situ functional assays. Genes Development 2013 Dec 1;27(23):2602-14.

Nasr, Z., Dow, L.E., Paquet, M., Chu, J., Ravindar, K., Somaiah, R., Deslongchamps, P., Porco, J.A. Jr, Lowe, S.W., Pelletier, J. Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. BMC Pharmacology and Toxicology 2013 Nov 13;14:58.

Nguyen, A.H., Tremblay, M., Haigh, K., Koumakpayi, I.H., Paquet, M., Pandolfi, P.P., Mes-Masson, A.M., Saad, F., Haigh, J.J., Bouchard, M. Gata3 antagonizes cancer progression in Pten-deficient prostates. Human Molecular Genetics 2013 Jun 15;22(12):2400-10.

Tsoi, M., Laguë, M.N., Boyer A., Paquet, M., Nadeau, M.E., Boerboom, D. Anti-VEGFA therapy reduces tumor growth and extends survival in a murine model of ovarian granulosa cell tumor. Translational Oncology 2013 June;1:6(3):226-33

Goulet, M.L., Olagnier, D., Xu, Z., Paz, S., Belgnaoui, S.M., Lafferty, E.I., Janelle, V., Arguello, M., Paquet, M., Ghneim, K., Richards, S., Smith, A., Wilkinson, P., Cameron, M., Kalinke, U., Qureshi, S., Lamarre, A., Haddad, E.K., Sekaly, R.P., Peri, S., Balachandran, S., Lin, R., Hiscott, J. Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. PLoS Pathology 2013 Apr;9(4)

Yuki, K.E., Eva, M.M., Richer, E., Chung, D., Paquet, M., Cellier, M., Canonne- Hergaux, F., Vaulont, S., Vidal, S.M., Malo, D., Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. PLoS One 2013 February;8(2)

Lapointe, E., Boyer A., Rico C., Paquet M., Franco, H., Gossen J., DeMayo F-J., Richards J.S., Boerboom, D. FZD1 Regulates Cumulus Expansion Genes and is Required for Normal Female Fertility. Biology of Reproduction 2012 November;87(5)104

Rico, C., Lagüe, M.N., Lefèvre, P., Dodelet-Devillers, A., Kumar, V., Paquet, M., Nadeau, M.E., Boerboom, D. Pharmacological targeting of mammalian target of rapamycin (mTOR) inhibits ovarian granulosa cell tumor growth. Carcinogenesis 2012 November;33(11):2283-92

Doody, K.M., Bussières-Marmen, S., Li, A., Paquet, M., Henderson, J.E. Tremblay, M. T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. Arthritis & Rheumatism 2012 March;64(3):752-61

Boyer, A., Yeh, J.R., Zhang, X., Paquet, M., Gaudin, A., Nagano, M.C. and Boerboom, D. Sustained CTNNB1 signaling in Sertoli cells downregulates spermatogonial stem cell activity via WNT4. PLoS One 2012 January;7(1):e29764

Richer, E., Yuki, K.E., Dauphinee, S.M., Larivière, L, Paquet, M., Malo, D. Impact of Usp18 and IFN signaling in Salmonella-induced typhlitis. Genes and Immununity 2011 October;12(7):531-43

Paquet M., El-Warrak A.O., Laguë M.N., Boerboom D. Atypical caudal duplication with phenotypic sex reversal in a dog. Journal of Veterinary Diagnostic Investigation 2011 September;23(5):1037-4

Diez, E., Zhu, L., Teatero, S.A., Paquet, M., Roy, M.F., Loredo-Osti, JC., Malo, D., Gruenheid, S. Identification and characterization of Cril, a locus controlling mortality during Citrobater rodentium infection in mice. Genes and Immununity 2011 June;12(4):280-90

Chevillard, G., Paquet, M., Blank, V. Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma. Blood 2011 February;117(6):2005-8

Laguë, M.N., Detmar, J., Paquet, M., Boyer, A., Richards, J.S., Adamson, S.L., Boerboom, D. Decidual PTEN expression is required for trophoblast invasion in the mouse. American Journal of Physiology: Endocrinology & Metabolism 2010 December;299(6):E936-46

Chevillard, G., Nouhi, Z., Anna, D., Paquet, M., Blank, V. Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene. FEBS Letters 2010 March;584(5):923-8

Hudon, V., Sabourin, S., Dydensborg, A.B., Kottis, V., Ghazi, A., Paquet, M., Crosby, K., Pomerleau, V., Uetani, N., Pause, A. Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin. Journal of Medical Genetics 2010 March;47(3):182-9

Nadeau, M.E., Kaartinen, M.J., Laguë, M.N., Paquet, M., Huneault, L.M., Boerboom, D. A mouse surgical model for metastatic ovarian granulosa cell tumor. Comparative Medicine 2009 December;59(6):553-6

Petroulakis, E., Parsyan, A., Dowling, R.J., LeBacquer, O., Martineau, Y., Bidinosti, M,. Larsson, O., Alain, T., Rong, L., Mamane, Y., Paquet, M., Furic, L., Topisirovic, I., Shahbazian, D., Livingstone, M., Costa-Mattioli, M., Teodoro, J.G., Sonenberg, N. P53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell 2009 November;16(5):439-46

Cadieux, C., Kedinger, V., Yao, L., Drossos, M., Paquet, M., Nepveu, A. MMTV-p75 and p110 CUX1 transgenic mice develop mammary tumors of various histological type. Cancer Research 2009 September;69(18):7188-97

Fan, H.Y., Liu, Z., Paquet, M., Wang, J., Lydon, J.P., DeMayo, F.J., Richards, J.S. Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells. Cancer Research 2009 August;69(16):6463-72

Dydensborg, A.B., Rose, A.A., Wilson, B.J., Grote, D., Paquet, M., Giguère, V., Siegel, P.M., Bouchard, M. GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Oncogene 2009 July;28(29):2634-42

Fernandez-Valdiva, R., Mukerjee, A., Ying, Y., Li, J., Paquet, M., DeMayo, F.J., Lydon, J.P. The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Developmental Biology 2009 April;328(1):127-39

Boyer, A., Paquet, M., Laguë, M.N., Hermo, L., Boerboom, D. Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis. Carcinogenesis 2009 May;30(5):869-78

Laguë, M.N., Paquet, M., Kaartinen, M.J., Chu, S., Jamin, S.P., Behringer, R.R., Fuller, P.J., Mitchell, A., Doré, M., Huneault, L.M., Richards, J.S., Boerboom, D. Synergistic effects of PTEN loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis 2008 November;29(11):2062-72

Boyer, A., Hermo, L., Paquet, M., Robaire, B., Boerboom, D. Seminiferous tubule degeneration and infertility in mice with sustained activation of WNT/CTNNB1 signaling in Sertoli cells. Biology of Reproduction 2008 September;79(3):475-85

Paquet, M., Penney, J., Boerboom, D. Lateral femoral hernias in a line of FVB/NHsd mice: a new confounding lesion linked to genetic background? Comparative Medicine 2008 August;58(4):395-8

Cadieux, C., Harada, R., Paquet, M., Côté, O., Trudel, M., Nepveu, A., Bouchard, M. Polycystic kidneys caused by sustained expression of CUX1 isoform P75. Journal of Biological Chemistry 2008 May;283(20):13817-24

Julien, S.G., Dube, N., Read, M., Penney, J., Paquet, M., Han, Y., Kennedy, B.P., Muller, W.J., Tremblay, M.L. Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nature Genetics 2007 January:1-9

Boerboom, D., Paquet, M., Hsieh, M., Liu, J., Sirois, J., Behringer, R.R., Taketo M.M., Richards, J.S. Misregulation of Wnt/ β-catenin signaling plays a key role in ovarian granulosa cell tumorigenesis. Cancer Research 2005 October;65(20):9206-15

Iskander, K., Gaikwad, A., Paquet, M., Long, I.I., D.J., Brayton, C., Barrios, R., Jaiswal, A.K. Lower induction of p53 and decreased apoptosis in NQO1-null mice leads to increased sensitivity of chemical-induced skin carcinogenesis. Cancer Research 2005 March;65(6):2054-8

Iskander, K., Paquet, M., Brayton, C., Jaiswal, A. Deficiency of NRH: Quinone Oxidoreductase 2 (NQO2)) Increases susceptibility to 7,12 Dimethylbenze(a)anthracene induced Skin Carcinogenesis. Cancer Research 2004 September;64(17):5925-8

Boyer, A., Paquet, M., Raiwet, D., Daneau, I., Harrison, W., Silversides, D. Rapid Genomic Identification of transgenic integration sites for mouse Insertional mutants. Biotechniques 2003 January;34(1):32-4