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     saram     

Sairam M. Ram, Ph.D.

Lab Director

IRCM

Département of Molecular Reproduction

110, avenue des Pins Ouest

Montréal (Québec)  H2W 1R7

Canada

Unité de recherche en reproduction

Tel.: (514) 987-5582

Fax: (514) 987-5585

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Research Interests: 

  • Molecular endocrinology and biochemistry of Gonadotropins and receptors
  • Ovarian/testicular function
  • Menopause
  • Andropause
  • Obesity
  • Ovarian Cancer
  • Novel genes

 

Summary of Results:

We are currently focusing our efforts in studying a genetically altered mouse model that shows hormonal imbalances/deficiencies that occur during reproductive aging, menopause and andropause (in males). In the genetically modified Follitropin Receptor Knockout (FORKO) mouse we recognize the potential for understanding the role of hormonal balances in a variety of health issues that impact women and men. These in general concern aging, menopause, infertility and andropause. In particular we have found that heterozygous mice that have only 50% of the functional follitropin gene lose their reproductive capacity much faster than normal females. In the "Menopause mouse” premature ovarian failure and infertility (in women) is related to the quality of gametes; the FORKO females that exhibit various symptoms and conditions that occur in menopause; like obesity, type II diabetes, hypertension, neural changes, as well as various tumors providing an experimental paradigm to study aging changes and potential remedial measures. The chronology of three conditions–abdominal obesity and cardiovascular function, ovarian tumors and hyperandrogenemia that are important in post menopausal women are addressed in the model.  We are currently exploring changes in gene repertoire in the affected target areas to identify their role in pathogenesis.   

 

List of Recent Publications : 

Belo, N., Sairam, M.R., and Dos Reis, A.M.: Impairment of the natriuretic peptide system in follitropin receptor knockout mice and reversal by estradiol: implications for obesity-associated hypertension in menopause. Endocrinology 149(3): 1399-1406, 2008.

Ebrahimian, T., Sairam, M.R., Schiffrin, E.L., and Touyz, R.M.: Cardiac hypertrophy is associated with altered thioredoxin and ASK1 signaling in a mouse model of menopause. Am. J. Physiol. Heart Circ. Physiol., August 1, 2008, (Epub ahead of print) PMID: 18676690.

Zhang, H., Chen, X., Aravindakshan, J., and Sairam, M.R.: Changes in adiponectin and inflammatory genes in response to hormonal imbalances in female mice and exacerbation of depot selective visceral adiposity by high fat diet: implications for insulin resistance. Endocrinology 148(12): 5667-5679, 2007. 

Chen, X., Aravindakshan, J., Yang, Y., and Sairam, M.R.: Early Alterations in Ovarian Surface Epithelial Cells and Induction of Ovarian Epithelial Tumors Triggered by Loss of FSH Receptor. Neoplasia 9 (6): 521-531, 2007. Article featured on Journal cover.

Rumora, L., Lovrić, J., Sairam, M.R., and Maysinger, D.: Impairments of heat shock protein expression and MAPK translocation in the central nervous system of follitropin receptor knockout mice. Exp. Gerontol. 42(7): 619-628, 2007.

Javeshghani, D., Sairam, M.R., Neves, M.F., Schiffrin, E.L., and Touyz, R.M.: Increased Blood Pressure, Vascular Inflammation and Endothelial Dysfunction in Androgen-Deficient Follitropin Receptor Knockout Male Mice. J. Amer. Soc. Hypertension 1(5): 353-361, 2007.

Sairam, M.R. and Babu, P.S.: The tale of follitropin receptor diversity: A recipe for fine tuning gonadal responses? Mol. Cell. Endocrinol. (2)260-262: 163-171, 2007.8.            Tiwari-Pandey, R., Aravindakshan, J., Yang, Y., and Sairam, M.R.: Normalization of Hormonal Imbalances, Ovarian Follicular Dynamics and Metabolic Effects in Follitropin Receptor Knockout (FORKO) Mice. Mol. Hum. Reprod. 13: 287-297, 2007.

Gao, J., Tiwari-Pandey, R., Samadfam, R., Yang, Y., Miao, D., Karaplis, A.C., Sairam, M.R., and Goltzman, D.: Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone (FSH). Endocrinology 148(6): 2613-2621, 2007.

Danilovich, N. and Sairam, M.R.: Recent female mouse models displaying advanced reproductive aging. Exp. Gerontol. 41(2): 117-122, 2006.11.       

Sun, L., Peng, Y., Sharrow, A.C., Iqbal, J., Zhang, Z., Papachristou, D.J., Zaidi, S., Zhu Ling-L., Yaroslavskiy, B.B., Zhou, H., Zallone, A., Sairam, M.R., Kumar, T.R., Bo, W., Braun, J., Cardoso-Landa, L., Schaffler, M.B., Moonga, B.S., Blair, H.C., and Zaidi, M.: FSH Directly Regulates Bone Mass: Implications for Understanding the Pathogenesis of Osteoporosis Due to Hypogonadism. Cell 125(2): 247-260, 2006.

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