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Rima-Slim

Rima Slim, PhD

Associate Professor

McGill University

Department: Human Genetics and Obstetrics-Gynecology

McGill University Health Center Research Institute, Glen Site, 1001 Décarie Blvd, Montréal (Québec)  H4A 3J1

Office : EM03210 / Lab : E012379

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Telephone : 514 934 1934 ext 44550 (office)

Lab: (514) 934-1934 ext 44519

URL: http://www.mcgill.ca/rslimlab/

Field of research:

Genetics of Female Reproduction

Resume of recent results:

The current research activities of my group are focused on (i) elucidating the exact role of NLRP7 in the patho-physiology of moles, (ii) investigating the role of NLRP7 and its inflammatory pathway in all types of moles, and (iii) identifying other genes for these conditions to help the patients.

 

Laboratory members

Name

Position

Email Address

Elie Akoury

Ph.D.

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Ramesh Reddy

Ph.D.

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Phuong Nguyen

Ph.D.

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Yassemine Khawajkie

M.Sc.

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Pierre Adrien Bolze

M.D / Ph.D

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Nawel Mechtouf

Clinical Coordinator/Research Assistant

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Publications (selection):

  1. Akoury E, Zhang L, Ao A, Slim R*. NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton. Hum Reprod 2014.
  2. Nguyen NM, Zhang L, Reddy R, Déry C, Arseneau J, Cheung A, Surti U, Hoffner L, Seoud M, Zaatari G, Bagga R, Srinivasan R, Coullin P, Ao A, Slim R*. Comprehensive genotype-phenotype correlations between NLRP7 mutations and the balance between embryonic tissue differentiation and trophoblastic proliferation. J Med Genet. 51(9):623-634, 2014.
  3. Singer H, Biswas A, Zimmer N, Messaed C, Oldenburg J, Slim R, El-Maarri O. NLRP7 inter-domain interactions: the NACHT-associated domain (NAD) is the physical mediator for oligomeric assembly. Mol Hum Reprod 20(10):990-1001, 2014.
  4. Nguyen NM, Slim R*. Genetics and Epigenetics of Recurrent Hydatidiform Moles: Basic Science and Genetic Counselling. Curr Obstet Gynecol Rep 3:55-64, 2014.
  5. Slim R* and Wallace E. NLRP7 and the genetics of hydatidiform moles: recent advances and new challenges. Front Immunol. 2013 Aug 20;4:242.
  6. Reddy R, Akoury E, Phuong NM Nguyen, Abdul-Rahman OA, Dery C, gupta N, Daley WP, Ao A, Landolsi H, Fisher R, Touitou I, Slim R*. Report of four new patients with protein-truncating mutations in C6orf221/KHDC3L and colocalization with NLRP7. Eur J Hum Genet 2012 Dec 12. doi: 10.1038/ejhg.2012.274. [Epub ahead of print].
  7. Slim R*, Coullin P, Diatta A-L, Chebaro W, Courtin D, Abdelhab S, Garcia A. NLRP7 and the Genetics of Postmolar Choriocarcinomas in Senegal. Mol Hum Reprod, 18(1):52-56, 2012.
  8. Messaed C, Akoury E, Djuric U, Zeng J, Saleh M, Gilbert, L, Seoud M, Qureshi S, Slim R. NLRP7 is required for normal cytokine secretion and co-localizes with the Golgi apparatus and the microtube organizing center. J Biol Chem 286(50):43313-23, 2011.
  9. Messaed C, Chebaro W, Brisset RDR, RittoreC, Cheung A, Arseneau J, Schneider A, Chen MF, Bernishke K, Surti U, Hoffner L, Sauthier P, Buckett W, Qian J, Lau NM,, Bagga R, Engert JC, Coullin P, Touitou I, and Slim R*. NLRP7 in the Spectrum of Reproductive Wastage: Rare Non-synonymous Variants Confer Genetic Susceptibility for Recurrent Reproductive Wastage. J Med Genet, Aug; 48(8):540-8, 2011.
  10. Qian J, Cheng Q, Murdoch S, Xu C, Jin F, Chebaro W, Zhang X, Gao H, Zhu Y, Slim R*, Xie X. The Genetics of Recurrent Hydatidiform Moles in China: Correlations between NLRP7 Mutations, Molar Genotypes, and Reproductive Outcomes. Mol Hum Reprod April 19, 2011 [EPub ahead of print].
  11. Choufani S, Shapiro JS, Susiarjo M, Butcher DT, Grafodatskaya D, Ferreira JC, Pinto D, Scherer SW, Schaeffer L, Caniggia I, Beyene J, Slim R,. Bartolomei MS, Weksberg R. Genome-wide DNA Methylation Profiling in Human Tissues of Uniparental Origin Identifies New Differentially Methylated Regions (DMRs) Associated with Imprinted Genes. Genome Res 21 (3):465-76, 2011.
  12. Deveault C, Qian J, Chebaro W, Ao A, Gilbert L, Mehio A, Khan R, Tan SL, Wischmeijer A, Coullin P, Xie X, Slim R*. NLRP7 mutations in women with diploid androgenetic and triploid moles: a proposed mechanism for mole formation. Hum Mol Genet Hum Mol Genet 18 (5):888-97, 2009.
  13. Deveault C, Qian J, Chebaro W, Ao A, Gilbert L, Mehio A, Khan R, Tan SL, Wischmeijer A, Coullin P, Xie X, Slim R*. NLRP7 mutations in women with diploid androgenetic and triploid moles: a proposed mechanism for mole formation. Hum Mol Genet Hum Mol Genet 18 (5):888-97, 2009.
  14. Qian J, Deveault C, Bagga R, Xie X, Slim R*. Women Heterozygous for NALP7/NLRP7 Mutations Are at Risk for Reproductive Wastage: Report of Two New Mutations. Hum Mutat 28(7) 741, 2007
  15. Murdoch S, Djuric U, Mazhar B, Seoud M, Khan R, Kuick R, Bagga R, Kircheisen R, Ao A, Ratti B, Hanash S, Rouleau G, Slim R *. Mutations in NALP7, a maternal effect gene, result in recurrent hydatidiform moles and reproductive wastage in humans. Nature Genet 38(3): 300-302, 2006.

 

Awards:

The Szulman Award, Magee-Womens Hospital of the University of Pittsburgh, Medical Center, Dept of Pathology, October 4, 2013

Hugh & Helen McPherson Memorial Award, Faculty of Medicine, McGill.

FRSQ Salary Award, Chercheur Boursier, Senior

Fraser Monat and McPherson Scholarship

FRSQ Salary Award, Chercheur Boursier, Junior II