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 simon wing 2     

Simon Wing, Ph.D.

Professor

McGill University and MUHC Research Institute

Dept. of Medicine

1001, Décarie blvd, room E02.7232

Montreal, Québec

H4A 3J1

Telephone: 514 934-1934 ext. 76184

Fax : 514 933-7951

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Research interests:

The role of the ubiquitin proteasome system in spermatogenesis.

Summary of results:

Our recent studies identify essential roles for the Huwe1 ubiquitin ligase in both proliferation and differentiation of spermatogonial stem cells and a role for the USP2 deubiquitinating enzyme in the sperm's ability to fertilize and oocyte.

Laboratory members:

Nom

Position

Adresse courriel

 Rohini Bose

 Graduate student

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 Erin Coyne

 Graduate student

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 Kai Sheng

 Graduate student

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 Nathalie Bédard

 Senior technician

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 Marie Plourde

 Technician

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List of publications:

  1. Bose R, Manku G, Culty M and Wing SS. Ubiquitin-proteasome system in spermatogenesis. Invited book chapter in Posttranslational Protein Modifications in the Reproductive System. Editor: Sutovsky P. Springer Science & Business Media, New York. Adv Exp Med Biol.2014: 759:181-213. doi: 10.1007/978-1-4939-0817-2_9.
  2. Yang Y*, Duguay D*, Bedard N, Rachalski A, Baquirin G, Na CH, Fahrenkrug J, Storch F, Peng J, Wing SS+ and Cermakian N+. Regulation of behavioural circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2. Biology Open 2012, 1: 789-801, doi: 10.1242/bio.20121990. *Equal contributions; +Corresponding authors
  3. Manku G, Wing SS and Culty M. Expression of the ubiquitin proteasome system in neonatal rat gonocytes and spermatogonia: role in gonocyte differentiation. Biol. Repro. 2012, 87: 1-18.
  4. Bedard N, Yang Y, Gregory M, Cyr DG, Suzuki J, Yu X, Clarke H, Chian RC, Hermo L, O’Flaherty C, Smith CE and Wing SS. Mice Lacking the USP2 Deubiquitinating Enzyme have Severe Male Sub-Fertility Associated with Defects in Fertilization and Sperm Motility. Biol. Repro. 2011, 85: 594-604.
  5. Lu Y, Bedard N, Chevalier S and Wing SS. Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.  PLoS ONE 2011; Jan 17, 6(1): e15936. doi:10.1371/journal.pone.0015936
  6. Sundaram P, Pang Z, Miao M, Yu L and Wing SS. USP19 Deubiquitinating Enzyme Regulates Levels of Major Myofibrillar Proteins in L6 Muscle Cells. Amer. J. Physiol. Endo & Metab 2009, 297: E1283-E1290.
  7. Liu Z, Miao D, Xia Q, Hermo L, and Wing SS. Regulated expression of the Ubiquitin Protein Ligase, E3Histone /LASU1/ Mule/ARF-BP1, during Spermatogenesis.   Dev. Dynamics 2007, 236: 2889-2898
  8. Liu Z, Oughtred R, and Wing SS. Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones. Mol. Cell. Biol. 2005; 25: 2819-2831

Awards:

Elected to American Society of Clinical Investigation