- 450 687-5010 Ext. 8830
- Centre INRS – Institut Armand-Frappier
531, boulevard des Prairies
Laval (Québec), Canada H7V 1B7
Our research projects aim to determine how exposure to medical or environmental chemicals during particular periods of sensitivity in life can alter male fertility.
Epidemiological evidence suggests a worldwide increase in male fertility issues associated with decreased sperm production, increased incidence of testicular cancer and genital tract anomalies in humans and various wild animals. Data accumulate, demonstrating an adverse effect of exposure to chemicals in the environment or of medical treatments on reproductive function. However, the cellular and molecular mechanisms involved in these effects on male fertility are still poorly documented. We seek to characterize these mechanisms in immature germ cells, the precursors of spermatozoa. Using in vivo and in vitro models in rodent and humans, we investigate the toxicity of the chemical environment, testing the cytotoxicity, impact on DNA damage, gene expression and epigenetic reprogramming in male germ cells.