Géraldine Delbes, PhD

Associate professor, INRS-Centre Armand Frappier-Santé biotechnologie

research axis 2

Address

Research interests

  • Reproductive toxicology
  • Endocrine disruptors and testis development
  • Developmental Origin of Health and Disease (DOHaD)

Our research projects aim to determine how exposure to medical or environmental chemicals during particular periods of sensitivity in life can alter male fertility.

Epidemiological evidence suggests a worldwide increase in male fertility issues associated with decreased sperm production, increased incidence of testicular cancer and genital tract anomalies in humans and various wild animals. Data accumulate, demonstrating an adverse effect of exposure to chemicals in the environment or of medical treatments on reproductive function. However, the cellular and molecular mechanisms involved in these effects on male fertility are still poorly documented. We seek to characterize these mechanisms in immature germ cells, the precursors of spermatozoa. Using in vivo and in vitro models in rodent and humans, we investigate the toxicity of the chemical environment, testing the cytotoxicity, impact on DNA damage, gene expression and epigenetic reprogramming in male germ cells.

Members of the laboratory

Natasha Letourneau
Undergraduate student
Natasha.Letourneau@inrs.ca

Rhizlane Elomri, MSc
PhD student
rhizlane.elomri@iaf.inrs.ca

Ghida Baalbaki, MSc
PhD student
ghida.baalbaki97@hotmail.com

Antoine Gillet, MSc
PhD student
antoine.gillet@inrs.ca

Publications