Research interests

  • How does the ovary produce competent occytes?
  • Genomic and transcriptomic analyses of the oocyte and the embryo
  • Follicular growth and differentiation using trancriptomics and the evaluation of the follicular quality

The main focus of our research is on the oocyte competence, which essentially depends on the follicle status. Our genomic tools allow us to discover and study markers of healthy follicles in both cattle and humans to improve practices particularly for in vitro fertilization. It seems that the mammalian ovary is able to determine whether the oocyte will be good or not. It now appears that endogenous hormones and also exogenous hormones (injection) can alter the quality of the follicle and incidentally that of the oocyte. It would be the same for environmental conditions such as the mother’s nutrition or metabolic status. We are interested in understanding how genes respond to these conditions and how the ovary can then modify the epigenomic baggage of the oocyte so that it is influence by with this information. Our study continues with the analysis of the transcriptome (the set of genes expressed in a tissue) and the epigenome (the packaging of each gene in a tissue) of the early bovine embryo thanks to the new embryoGENE platform. This analysis allows us to see the effect of any manipulations on an embryo from simple culture to cloning or transgenesis.

Members of the laboratory

Asma Arjoune
PhD student

Martine Boulet, BSc
MSc student

Camila Bruna De Lima, PhD

Chloé Fortin, MSc
PhD student

Simon Lafontaine, MSc
PhD student

Meishong Shi, MSc
PhD student

Chongyand WU, MSc
PhD student

Pagricia Tremblay, MSc
PhD student

Ying Zhang, MSc
PhD student